Illinois at Indiana odds, picks and predictions

Analyzing Friday’s Illinois at Indiana odds and lines, with college football expert picks, predictions and best bets.

The Indiana Hoosiers (0-0) will welcome the Illinois Fighting Illini (1-0)  to Memorial Stadium Friday with kickoff scheduled for 8 p.m. ET (FS1). Below, we analyze Tipico Sportsbook‘s lines around the Illinois at Indiana odds, and make our expert college football picks and predictions.

The Hoosiers will be coming into this season hoping to rebound from a horrible 2021 season in which they won just 2 games. Indiana won’t have QB Michael Penix Jr. leading the way, but rather QB Jack Tuttle.

Tuttle played in 6 games and had 2 touchdowns and 5 interceptions. Indiana’s leading rusher and top receivers won’t be back, so it’ll be a new roster looking to bring in a new generation of Hoosiers talent.

Illinois is coming off a 38-6 win over Wyoming. The Fighting Illini have a new quarterback in Syracuse transfer Tommy Devito, who has 2 touchdowns and 0 interceptions in the season opener.

Devito will have redshirt junior RB Chase Brown as well. Brown led the team in rushing with 1,005 yards a season ago. The Illini were 5-7 last season, 4-5 in Big Ten action.

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Illinois at Indiana odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:14 a.m. ET.

  • Money line (ML): Illinois +105 (bet $100 to win $105) | Indiana -130 (bet $130 to win $100)
  • Against the spread (ATS): Illinois +1.5 (-105) | Indiana -1.5 (-115)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Illinois at Indiana picks and predictions

Prediction

Illinois 24, Indiana 21

Money line

BET ILLINOIS (+105).

Illinois has a game under its belt and is returning many talented players while Indiana is a bit more of a wild card and is coming off a horrific season. While Tuttle may be an upgrade, he proved little in his time a season ago.

Indiana lost every Big Ten game last season and only won against Idaho and Western Kentucky. At home, it won 1 game and lost to 2 unranked Big Ten opponents by more than 20 points each.

Tom Allen retained his job as the Indiana coach, and I don’t see him doing a much better job this time around. That said, Illinois has a trusted quarterback leading the way and a proven rusher.

Couple it all, and I’ll take the plus-money value for the road side.

Against the spread

PASS.

I’ll take the plus-money odds instead of a 1.5-point spread.

Over/Under

LEAN UNDER 45.5 (-108).

The Indiana offense scored more than 15 in just 1 Big Ten game last season. While it may have a new quarterback, Allen is still leading the way and he isn’t a proven winner with the Hoosiers.

Illinois, on the other hand, did put 38 in its opener, but the Fighting Illini ran for more yards than they passed. The Indiana front line should have a better chance to show down that run.

With the Hoosiers potentially able to match the strength of the Fighting Illini front, scoring could be limited if both offenses are sloppy throughout this conference battle.

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