Houston Astros at New York Yankees odds, picks and predictions

Analyzing Wednesday’s Houston Astros at New York Yankees odds and lines, with MLB expert picks, predictions and best bets.

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The Houston Astros (12-23) take on the New York Yankees (24-13) Wednesday in the 2nd game of a 3-game set at Yankee Stadium at 7:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: Yankees lead 5-0

The Astros dropped their 3rd-straight game Tuesday with a 10-3 setback in the opener. The Yankees mauled RHP Justin Verlander for 7 runs on 8 hits over 5 innings. While scoring 3 runs, Houston had just 3 hits in the game. A reboot may be coming if things don’t turn around soon.

The Yankees won their 4th straight and 5th in 6 games as they lead the AL in wins (24) entering Wednesday’s action. LF Alex Verdugo had 3 hits and 4 RBIs Tuesday, and RF Juan Soto smacked 3 hits of his own. Soto is hitting .329 with 8 homers and 28 RBIs in what is shaping up to potentially be an MVP season.

Astros at Yankees projected starters

RHP Spencer Arrighetti vs. LHP Carlos Rodon

Arrighetti (0-3, 8.27 ERA) makes his 5th start. The rookie has a 1.96 WHIP, 5.5 BB/9 and 11.6 K/9 in 16 1/3 innings.

  • Last start: No-decision, 5 2/3 IP, 2 ER, 4 H, 3 BB, 6 K in 8-2 home win vs. Houston Astros Thursday
  • Has never faced Yankees
  • Missing bats with his curveball (.167 BA), but other pitches being hit: fastball (.333), cutter (.313), sweeper (.429) and changeup (.667)

Rodon (2-2, 3.68 ERA) makes his 8th start. He has a 1.28 WHIP, 3.4 BB/9 and 8.8 K/9 in 36 2/3 innings.

  • Last start: Loss, 4 IP, 6 ER, 8 H, 0 BB, 6 K in 7-2 defeat at Baltimore Orioles Thursday
  • March 29 vs. Astros: No-decision, 4 1/3 IP, 1 ER, 5 H, 3 BB, 4 K in 7-1 win
  • Last 5 starts vs. Astros: 2-0, 3.12 ERA (26 IP, 9 ER), 0.92 WHIP, 31 K

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Astros at Yankees odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:56 p.m. ET.

  • Moneyline (ML): Astros +130 (bet $100 to win $130) | Yankees -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros +1.5 (-155) | Yankees -1.5 (+125)
  • Over/Under (O/U): 9.5 (O: -105 | U: -115)

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Astros at Yankees picks and predictions

Prediction

Yankees 9, Astros 5

Moneyline

The Yankees have won 8 straight against the Astros, dating back to last season. I look for this to be a slugfest with New York’s bats reigning supreme. The Yankees’ -155 ML isn’t priced out of my range here, but I’m going with the run line below.

PASS on a moneyline wager.

Run line/Against the spread

Over the last 10 head-to-head meetings, the Yankees have won 9, and 6 of those were by multiple runs. Over their last 10 overall, they’ve won 7, and 6 of those were by multiple runs.

Take YANKEES -1.5 (+125).

Over/Under

The wind is slated to be blowing out to right-center at 9 mph on a 77-degree evening. Rodon isn’t as good as his numbers suggest with a .273 BABIP and 4.78 FIP. Arrighetti has been terrible. This one goes OVER 9.5 (-105).

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