The Houston Astros (27-19) and the Milwaukee Brewers (25-21) open a 3-game interleague series Monday at American Family Field. First pitch is scheduled for 7:30 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Brewers odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting since a 2-2 series split in 2019
The Astros have rolled to 7 consecutive victories, moving within 2 games of the first-place Texas Rangers in the AL West. Houston enters with a 13-8 record on the road while going 10-5 in 15 interleague games. The Astros are 6-1 in the past 7 games against a right-handed starting pitcher, too.
The Brewers lead the Pittsburgh Pirates by 1 game in the NL Central, although Milwaukee has won just twice in the past 6 games overall. The Brew Crew have managed an 11-7 record in interleague play this season and are 24-10 record in their past 34 interleague games.
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Astros at Brewers projected starters
RHP Cristian Javier vs. RHP Corbin Burnes
Javier (4-1, 3.25 ERA) makes his 10th start. He has a 0.97 WHIP, 2.1 BB/9 and 10.1 K/9 in 52 2/3 innings.
- Last start: Win, 6 IP, 1 ER, 2 H, 2 BB, 5 K in a 7-3 home win vs. the Chicago Cubs Tuesday
- Road splits this season: 1-0, 3.60 ERA (25 IP, 10 ER), .161 OBA in 4 starts
Burnes (4-3, 3.48 ERA) makes his 10th start. He has a 1.16 WHIP, 3.3 BB/9 and 8.0 K/9 in 51 2/3 IP innings.
- Last start: Loss, 6 IP, 3 ER, 8 H, 1 BB, 7 K in a 3-0 road loss vs. the St. Louis Cardinals Wednesday
- Home splits this season: 2-0, 3.80 ERA (21 1/3 IP, 9 ER), .244 OBA in 4 starts
Astros at Brewers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:53 a.m. ET.
- Moneyline (ML): Astros -115 (bet $115 to win $100) | Rays -105 (bet $105 to win $100)
- Run line (RL)/Against the spread (ATS): Astros -1.5 (+150) | Brewers +1.5 (-185)
- Over/Under (O/U): 8 (O: -105 | U: -115)
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Astros at Brewers picks and predictions
Prediction
Astros 4, Brewers 3
Moneyline
The ASTROS (-115) are on a roll, stacking 7 wins in a row. They’re also 4-0 in the past 4 interleague road outings, 10-1 in the past 11 games on grass, 6-1 in the last 7 against a right-handed starting pitcher and 31-12 in the past 43 on the road.
The Brewers have dropped 4 of the past 5 games overall, and Milwaukee is 1-4 in the past 5 outings against teams with a winning record, too.
Run line/Against the spread
The Brewers +1.5 (-185) are a little pricey if you want to take the home team, but you can’t bring yourself to take Milwaukee straight up.
While the Astros are 14-38 in the past 52 trips to Milwaukee, that’s a bit misleading since Houston hasn’t been to Cream City since 2019.
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Over/Under
The UNDER 8 (-115) is the best play on the board in this interleague series opener.
The Under has cashed in 8 of the past 11 games for the Astros and is 6-1 in the past 7 tries against teams with a winning overall record. The Under is 5-0 in their past 5 on the road overall too, while cashing in 6 in a row on the road vs. right-handed pitchers.
The Under is 12-4 in Milwaukee’s past 16 games against AL West foes and is 6-2-1 in the past 9 interleague home outings. The Under is also 9-4 in the past 13 series openers for the Brewers, too.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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