Houston Astros at Los Angeles Angels odds, picks and predictions

Analyzing Wednesday’s Houston Astros at Los Angeles Angels odds and lines, with MLB expert picks, predictions and best bets.

The Houston Astros (18-18) conclude a 3-game series against the Los Angeles Angels (20-17) on Wednesday at Angel Stadium. First pitch is scheduled for 4:07 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Angels odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

The Astros snapped a 3-game losing skid with a 3-1 victory Tuesday. Houston has tallied a 4-6 record in its last 10 contests.

The Angels lost on Tuesday despite RHP Shohei Ohtani fanning 7 and surpassing Babe Ruth for the most all-time strikeouts for a player who has hit 100-plus home runs. Los Angeles has gone 6-4 in its last 10 games but has lost 3 of its last 4 contests.

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Astros at Angels projected starters

RHP Cristian Javier vs. RHP Griffin Canning

Javier (2-1, 3.54 ERA) makes his 8th start. He has a 1.06 WHIP, 2.0 BB/9 and 9.5 K/9 through 40 2/3 IP.

  • Has registered 5 or more strikeouts in 6 of his 7 starts
  • Boasts a 3-1 record with a 2.59 ERA, 0.93 WHIP and 14.9 K/9 in 4 starts and 4 relief appearances in his career against the Angels

Canning (2-0, 5.31 ERA) makes his 5th start. He has a 1.33 WHIP, 3.5 BB/9 and 8.0 K/9 through 20 1/3 IP.

  • Has given up multiple ER in each of his first 4 starts
  • Owns an 0-1 record with a 9.22 ERA, 2.20 WHIP and 9.2 K/9 in 4 career starts against the Astros

Astros at Angels odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:11 a.m. ET.

  • Moneyline (ML): Astros -130 (bet $130 to win $100) | Angels +110 (bet $100 to win $110)
  • Run line (RL)/Against the spread (ATS): Astros -1.5 (+125) | Angels +1.5 (-155)
  • Over/Under (O/U): 9.5 (O: -110 | U: -110)

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Astros at Angels picks and predictions

Prediction

Astros 5, Angels 3

Moneyline

The ASTROS (-125) have a massive pitching advantage with Javier on the mound even though Canning has gone 2-0 in his first 4 starts. Houston is 14-6 in the last 20 meetings in Los Angeles and 57-27 in the last 84 meetings overall.

Run line/Against the spread

ASTROS -1.5 (+125) is how I’d wager on the run line with Javier pitching for Houston. The Astros should also have success against Canning in Wednesday’s AL West bout as he’s coming off a start where he surrendered 5 earned runs to the St. Louis Cardinals on Thursday.

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Over/Under

UNDER 9.5 (-110) is the lean in this game with Javier having success against the Angels in his career. The Astros are 6-4 to the Under in their last 10 games overall.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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