The Washington Commanders (7-6-1) travel to California to take on the NFC West champion San Fransisco 49ers (10-4) Saturday at 4 p.m. ET (CBS). Below, we look at Commanders vs. 49ers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The 49ers wrapped up the division title and a playoff berth with a 21-13 win in Week 15 over the Seattle Seahawks as 3.5-point favorites. They now turn their attention to catching the Minnesota Vikings for the No. 2 playoff seed.
Washington, after its 20-12 home loss to the New York Giants as 4-point favorites on Sunday, find themselves as the No. 7 seed in the NFC playoff picture. This game will be a difficult road test for a team that loves to run the ball and does not have the offense to put up a lot of points.
The 49ers also hope to pound the ball in the run game, but they have a more explosive passing offense which could be the key in this game.
Also see: All Week 16 odds and lines
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Commanders at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 1:18 a.m. ET.
- Moneyline (ML): Commanders +270 (bet $100 to win $270) | 49ers -330 (bet $330 to win $100)
- Against the spread (ATS): Commanders +7 (-114) | 49ers -7 (-106)
- Over/Under (O/U): 39.5 (O: -109 | U: -111)
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2022 betting stats
- ML: Commanders 7-6-1 | 49ers 10-4
- ATS: Commanders 7-6-1 | 49ers 9-5
- O/U: Commanders 4-9-1 | Commanders 6-8
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Commanders vs. 49ers head-to-head
The 49ers lead this all-time series 18-11-1, but the teams have split the last 2 games. Washington won the 2020 meeting 23-15 in San Francisco, while the 49ers won the 2019 matchup 9-0 in Washington.
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