The USC Trojans (2-2, 1-2 Pac-12) and Colorado Buffaloes (1-3, 0-1) meet Saturday at Folsom Field in Boulder, Colorado. Kickoff is scheduled for 2 p.m. ET. Below, we look at the USC vs. Colorado odds and lines; check back for our college football picks and predictions.
The Trojans have alternated wins and losses through four outings, they fired their head coach earlier this month and the team suffered its first loss at home to Oregon State in 61 years. This is rock bottom for USC.
The Buffaloes were dusted 35-13 at Arizona State last time out, dropping their third consecutive game. The Buffs have scored 20 total points across the past three outings, and CU has covered just once in four tries.
USC at Colorado odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 10:30 a.m. ET.
- Money line: USC -300 (bet $300 to win $100) | Colorado +230 (bet $100 to win $230)
- Against the spread (ATS): USC -6.5, -125 (bet $125 to win $100) | Colorado +6.5, +102 (bet $100 to win $102)
- Over/Under (O/U): 50.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
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2021 betting stats:
- ML: USC 2-2 | Colorado 1-3
- ATS: USC 2-2 | Colorado 1-3
- O/U: USC 2-2 | Colorado 1-3
USC at Colorado head-to-head
The Trojans are a perfect 14-0 in the all-time series against the Buffaloes, including a 35-31 win Oct. 25, 2019 in the most recent meeting in Boulder. USC has averaged 34.7 PPG across the past three meetings with Colorado.
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