The Stanford Cardinal (0-1) and USC Trojans (1-0) renew their annual rivalry this Saturday at 7:30 p.m. ET in L.A. Memorial Coliseum. Below, we look at Stanford at USC odds and lines; check back for our college football picks and predictions.
Rankings according to the USA TODAY AFCA Coaches Poll.
The preseason No. 14 Trojans pulled away late in their opener, a 30-7 win over San Jose State. Star QB Kedon Slovis went 24-for-36 for 256 yards and 2 TD, though the defense showed some holes through the air as San Jose State threw for 308 yards. USC has now covered four of its last five games dating back to last season.
Stanford’s opener was ugly in an early (9:00 a.m. PT) neutral-site game against Kansas State in Dallas Saturday. The Cardinal mustered just seven points and 233 total yards of total offense in a 24-7 loss. Its once-vaunted running game averaged 1.7 yards per carry with little rhythm from their two-quarterback rotation through the air (6.5 yards per attempt).
Stanford at USC odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 2:00 p.m. ET.
- Money line: Stanford +600 (bet $100 to win $600) | USC -1000 (bet $1,000 to win $100)
- Against the spread/ATS: Stanford +17.5, -115 (bet $115 to win $100) | USC -17.5, -105 (bet $105 to win $100)
- Total (Over/Under): 51.5, O: -103 (bet $103 to win $100) | U: -117 (bet $117 to win $100)
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2021 betting stats:
- ML: Stanford 4-2 | USC 5-1
- ATS: Stanford 3-2-1 | USC 3-3
- O/U: Stanford 3-3 | USC 1-5
Stanford at USC head-to-head
Saturday marks the 100th meeting between these two in a long-standing rivalry. They didn’t face each other in 2020 due to the COVID-shortened season; the last time they missed a year was during World War II. USC holds the all-time series lead 63-33-3.
More recently, USC has won three of the last four games in this series, beating Stanford in their last two home games by a combined 87-44 score.
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