In Week 11, the NFL brings us a prime-time international game as the San Francisco 49ers (5-4) and Arizona Cardinals (4-6) face each other for the first time this season Monday night. Kickoff is at 8:15 p.m. ET at Estadio Azteca in Mexico City (ESPN). Below, we look at 49ers vs. Cardinals odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The 49ers came off their bye week to beat the Los Angeles Chargers 22-16 Sunday night, giving them a second-straight win. They rushed for 157 yards as a team in the return of RB Elijah Mitchell from injured reserve, who led the team with 89 yards on 18 carries. The defense allowed only 238 total yards from the Chargers, although the Niners were unable to cover the 7-point spread in the win.
The Cardinals, in a battle of backup quarterbacks starting in place of injured starters, defeated the Los Angeles Rams 27-17 on Sunday on the road as 3.5-point underdogs. RB James Conner rushed for 69 yards and 2 touchdowns in 21 carries and the defense limited the Rams to 256 yards of total offense, 3-of-11 on third down, and they forced 2 turnovers.
Also see: All Week 11 odds and lines
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49ers vs. Cardinals odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:55 a.m. ET.
- Moneyline (ML): 49ers -260 (bet $260 to win $100) | Cardinals +195 (bet $100 to win $195)
- Against the spread (ATS): 49ers -6 (-109) | Cardinals +6 (-111)
- Over/Under (O/U): 45 (O: -110 | U: -110)
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2022 betting stats
- ML: 49ers 5-4 | Cardinals 4-6
- ATS: 49ers 4-5 | Cardinals 5-5
- O/U: 49ers 3-6 | Cardinals 5-5
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49ers vs. Cardinals head-to-head
The Cardinals and 49ers have played each other 61 times dating back to 1951. The 49ers lead the all-time series 32-29, although the Cardinals have won 3 of the last 4 meetings and are 11-3 against the 49ers dating back to 2015.
Cardinals QB Kyler Murray is 2-3 in 5 career starts against the 49ers since he entered the league, and backup QB Colt McCoy beat the 49ers last year starting in place of Murray.
49ers QB Jimmy Garoppolo is 3-2 in 5 career starts against Arizona and 2-2 as a member of the 49ers against them.
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