It’s only Week 8, but the Los Angeles Rams (3-3) and San Francisco 49ers (3-4) will square off for the 2nd time this season Sunday. Kickoff from SoFi Stadium will be at 4:25 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The 49ers have lost 2 games in a row, falling at the Atlanta Falcons in Week 6 and at home to the Kansas City Chiefs Sunday. The Chiefs made the win look easy, too, winning 44-23 thanks to 30 second-half points. The 49ers acquired RB Christian McCaffrey last week and he played Sunday in a somewhat of a limited role — 8 carries for 38 yards and 2 receptions for 24 yards. Expect him to get more touches against the Rams.
Los Angeles is coming off a bye for this division matchup at home. In the Rams’ last game, they beat the Carolina Panthers 24-10 in L.A. to snap a 2-game losing streak. The Rams lost their first meeting with the 49ers 24-9 back in Week 4 in Santa Clara. Los Angeles ranks 28th in points per game (17.3) this season.
Also see: All Week 8 odds and lines
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49ers at Rams odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:30 p.m. ET.
- Moneyline (ML): 49ers -135 (bet $135 to win $100) | Rams +110 (bet $100 to win $110)
- Against the spread (ATS): 49ers -2.5 (-110) | Rams +2.5 (-110)
- Over/Under (O/U): 42.5 (O: -112 | U: -108)
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2022 betting stats
- ML: 49ers 3-4 | Rams 3-3
- ATS: 49ers 3-4 | Rams 2-4
- O/U: 49ers 2-5 | Rams 1-5
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49ers vs. Rams head-to-head
There’s no question which team has owned this rivalry in recent years. The 49ers have won 7 of the last 8 meetings dating back to 2019, including their most recent meeting in Week 4. San Francisco has won 7 straight regular-season meetings, too.
The Rams’ only win against the 49ers in their last 8 attempts was in the NFC title game in January behind a 20-17 victory at home. The 49ers are a perfect 6-0 ATS in the last 6 meetings of this series, with the total going Under in 5 of those 6 games.
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