First look: San Francisco 49ers at LA Rams odds and lines

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The San Francisco 49ers (1-1) and LA Rams (0-2) will renew their rivalry Sunday in an NFC West matchup. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).

Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

Both teams are coming off losses in Week 2. The 49ers were upset by the Minnesota Vikings as 4.5-point favorites, losing 23-17 on the road in Minneapolis. They now sit at 1-1 and will look to avoid a dreaded 1-2 start as the defending NFC champions. RB Christian McCaffrey (calf/Achilles) remains out after being placed on injured reserve.

The Rams are 0-2 for the first time since 2011 after losing back-to-back games to the Detroit Lions and Arizona Cardinals. They were blown out by the Cardinals Sunday, 41-10, the 2nd-worst loss of Sean McVay’s head-coaching career. WR Puka Nacua (knee) is on injured reserve, and in Sunday’s loss, WR Cooper Kupp exited early with an ankle injury.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NFL odds. Lines last updated Monday at 9:51 a.m. ET.

Moneyline (ML): 49ers -375 (bet $375 to win $100) | Rams +300 (bet $100 to win $300)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -115 | U: -105)

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2024 betting stats

ML: 49ers 1-1 | Rams 0-2
ATS: 49ers 1-1 | Rams 0-2
O/U: 49ers 1-1 | Rams 1-1

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49ers vs. Rams head-to-head

The 49ers have owned the Rams in recent years, winning 9 of their last 11 meetings. Their only 2 losses were in Week 18 last season when both teams rested their starters and in the NFC title game 3 years ago, which punched the Rams’ ticket to the Super Bowl.

The Rams are 2-0 ATS in their last 2 games against the 49ers but previously failed to cover the spread in 7 straight. The total has gone Over in 3 consecutive meetings between these teams and is 5-5 in their last 10 games.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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