First look: San Francisco 49ers at Green Bay Packers odds and lines

Looking at Saturday’s San Francisco 49ers at Green Bay Packers Divisional Round NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers and Green Bay Packers clash in an NFC Divisional Round playoff game Saturday. The showdown at Lambeau Field is slated for an 8:15 p.m. ET kickoff. Below, we look at the 49ers vs. Packers odds and lines; check back for our NFL picks and predictions.

San Francisco defeated the Dallas Cowboys 23-17 in a wild-card game. The 49ers leveraged 14 Dallas penalties in clocking their third consecutive victory and scored 23 of the game’s first 30 points. San Francisco went 3-5 over their first eight games this season but are 8-2 since.

The Packers earned a bye in the Wild Card Round by finishing as the top seed in the NFC. Green Bay is 5-1 over its last six games and tallied 30 or more points in five of those games. Green Bay is 8-0 at home this season; six of those eight games were decided by two-or-more possessions.

Also see: All Divisional Round odds and lines

49ers at Packers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 8:28 a.m. ET.

  • Money line: 49ers +200 (bet $100 to win $200) | Packers -250 (bet $250 to win $100)
  • Against the spread (ATS): 49ers +5.5, -108 (bet $108 to win $100) | Packers -5.5, -112 (bet $112 to win $100)
  • Over/Under (O/U): 47.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

Also see: Betting 101

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2021-22 betting stats:

  • ML: 49ers 11-7 | Packers 13-4
  • ATS: 49ers 10-8 | Packers 12-5
  • O/U: 49ers 8-10 | Packers 8-9

49ers at Packers head-to-head

The ‘Niners fell 30-28 at home to the Packers Sept. 26.

The two sides leapfrogged each other twice in the final 40 seconds. San Francisco took a 28-27 lead on a touchdown with 37 seconds left but Green Bay got a PK Mason Crosby 51-yard field goal as time expired for the victory. Overall, the Packers outgained the 49ers 353 yards to 298 and were the beneficiaries of a plus-2 in the turnover battle.

Green Bay has beaten San Francisco each of the last two seasons (34-17 in 2020) and has won four of six games against the ‘Niners since 2015 (3-3 ATS).  The Packers lead the all-time series 38-32-1.

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