With 4 weeks of the 2022 NFL season done, the Philadelphia Eagles (4-0) head on the road to take on the Arizona Cardinals (2-2) for a Sunday late-afternoon conference matchup. Kickoff is 4:25 p.m. ET at State Farm Stadium (FOX). Below, we look at Eagles vs. Cardinals odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Eagles continued their undefeated start of the season with a 29-21 win over the Jacksonville Jaguars. They forced 5 turnovers in the win and have been dominant on both sides of the ball. They average 28.7 points per game on offense and have forced 10 turnovers on defense.
The Cardinals evened their record to 2-2 Sunday with a 26-16 road win over the Carolina Panthers, scoring 23 unanswered points after entering halftime trailing 10-3. QB Kyler Murray threw 2 touchdown passes and rushed for another in the win.
Also see: All Week 5 odds and lines
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Eagles at Cardinals odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:36 p.m. ET.
- Moneyline (ML): Eagles -230 (bet $230 to win $100) | Cardinals +190 (bet $100 to win $190)
- Against the spread (ATS): Eagles -5.5 (-108) | Cardinals +5.5 (-112)
- Over/Under (O/U): 49.5 (O: -115 | U: -107)
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2022 betting stats
- ML: Eagles 4-0| Cardinals 2-2
- ATS: Eagles 3-1 | Cardinals 2-2
- O/U: Eagles 2-2 | Cardinals 1-2-1
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Eagles vs. Cardinals head-to-head
The Eagles and Cardinals have met 121 times in their history dating back to 1935, including 3 postseason games.
The Cardinals lead the all-time series 60-56-5. They won the last matchup, a 33-26 home win in 2020 and have won 3 of the last 4 meetings. The Cardinals are 6-2 against the Eagles, dating back to the 2008 NFC Championship Game, when the Cardinals won to make it to the Super Bowl.
The Eagles have not beaten the Cardinals in State Farm Stadium since it opened in 2005.
Murray is 1-0 in his career against the Eagles, and QB Jalen Hurts is 0-1 against the Cardinals.
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