First look: LA Rams at San Francisco 49ers odds and lines

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Fresh off wins in Week 14, the LA Rams (7-6) and San Francisco 49ers (6-7) will square off Thursday night to open Week 15 as the 2024 season nears its end. Kickoff from Levi’s Stadium is set for 8:15 p.m. ET (Prime Video). Below, we look at Rams vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Rams took down the Buffalo Bills Sunday afternoon as 3.5-point underdogs in what was one of the best games of the season so far. They outdueled QB Josh Allen and the Bills offense, winning 44-42 at home to creep above .500 for the first time all year. The 2 teams combined for 902 yards and 6 touchdowns with no turnovers or sacks, a near-perfect game from each offense.

The 49ers won in dominant fashion against the Chicago Bears, beating them 38-13 at home Sunday despite being without RB Christian McCaffrey and several other key starters. The 49ers outgained the Bears 452-162, averaging a whopping 7.4 yards per play. QB Brock Purdy threw for 325 yards and 2 touchdowns in the win.

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Rams at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 9:05 a.m. ET.

Moneyline (ML): Rams +110 (bet $100 to win $110) | 49ers -135 (bet $135 to win $100)
Against the spread (ATS): Rams +2 (-110) | 49ers -2 (-110)
Over/Under (O/U): 48.5 (O: -110 | U: -110)

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2024 betting stats

ML: Rams 7-6 | 49ers 6-7
ATS: Rams 6-7 | 49ers 5-8
O/U: Rams 7-6 | 49ers 7-5-1

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Rams vs. 49ers head-to-head

The Rams and 49ers have met 10 times since the start of the 2020 season, and San Francisco holds the advantage, 7-3, in those games. The 49ers are also 7-3 ATS, but it’s the Rams who have covered in each of their last 3 meetings — while also winning the last 2 games straight up.

When they played in Week 3, the Rams stunned the 49ers, 27-24, as 6.5-point underdogs at home. They erased a 21-7 second-half deficit to beat the 49ers by 3 points, avoiding an 0-3 start to the year. The Rams also beat the 49ers in Week 18 of last season when both teams were resting their starters.

Since 2020, the O/U is evenly split with a record of 5-5 in Rams-49ers games.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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