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The Detroit Lions (13-2) and San Francisco 49ers (6-9) meet at Levi’s Stadium in Week 17 for Monday Night Football. Kickoff in the rematch of last season’s NFC Championship Game is scheduled for 8:15 p.m. ET (ESPN / ABC / ESPN+). Below, we look at Lions vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Lions got back in the win column with a 34-17 win at the Chicago Bears Sunday as 6.5-point favorites. QB Jared Goff went 23 of 32 for 336 yards with 3 TDs.
The 49ers have dropped back-to-back games after falling 29-17 at the Miami Dolphins Sunday as 2-point favorites. QB Brock Purdy went 26 of 40 for 313 yards with 2 TDs and an INT.
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Lions at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 10:35 a.m. ET.
- Moneyline (ML): Lions -190 (bet $190 to win $100) | 49ers +155 (bet $100 to win $155)
- Against the spread (ATS): Lions -3.5 (-110) | 49ers +3.5 (-110)
- Over/Under (O/U): 51.5 (O: -110 | U: -110)
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2024 betting stats
- ML: Lions 13-2 | 49ers 6-9
- ATS: Lions 10-5 | 49ers 5-10
- O/U: Lions 8-6-1 | 49ers 8-6-1
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Lions vs. 49ers head-to-head
The Lions and 49ers have a storied history, meeting 66 times since 1950. The 49ers lead the series 38-27-1.
In their last meeting Jan. 28, Detroit covered as a 7.5-point underdog in a 34-31 San Francisco home win as the Over (53.5) hit in the NFC Championship Game.
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