Week 4 features a battle between two unbeaten teams in the NFC West as the Arizona Cardinals (3-0) visit the Los Angeles Rams (3-0) Sunday afternoon. Kickoff from SoFi Stadium will be at 4:05 p.m. ET. Below, we look at the Cardinals vs. Rams odds and lines; check back for our NFL picks and predictions.
The Cardinals are fresh off a comeback 31-19 win over the Jacksonville JaguarsSunday. They trailed 13-7 at halftime but outscored Jacksonville 24-6 in the second half to secure their third straight win. QB Kyler Murray looks like an MVP frontrunner with 10 total touchdowns and more than 1,100 yards through three games, helping carry the Cardinals offense, which ranks first in the NFL in scoring.
The Rams dominated the Tampa Bay Buccaneers in Week 3, winning at home by a score of 34-24. They never trailed Tampa Bay in the game and have only been behind for 2:04 all season, cruising to a 3-0 start with double-digit wins over the Bucs and Chicago Bears. QB Matthew Stafford is tied with Murray for the best MVP odds in the NFL at +600, throwing 9 touchdown passes and only 1 interception.
Also see: All Week 4 odds and lines
Cardinals at Rams odds, spread and line
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 3 p.m. ET.
- Money line: Cardinlas +190 (bet $100 to win $190) | Rams -240 (bet $240 to win $100)
- Against the spread (ATS): Cardinals +5.5, -107 (bet $107 to win $100) | Rams -5.5, -115 (bet $115 to win $100)
- Total (O/U): 54.5, Over -108 (bet $108 to win $100) | Under -112 (bet $112 to win $100)
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2021 betting stats:
- ML: Cardinals 3-0 | Rams 3-0
- ATS: Cardinals 2-1 | Rams 2-1
- O/U: Cardinals 1-2 | Rams 3-0
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Cardinals at Rams head-to-head
The Rams have owned the Cardinals in the last four years with Sean McVay as their head coach. Los Angeles has won eight straight against Arizona, scoring at least 30 points in seven of those games. The Rams’ average margin of victory is 31-11, winning by double-digits seven times.
The Rams own the all-time series 45-38-2, as well. Last season, they won 18-7 in Week 17 when QB Jared Goff was injured, also beating the Cardinals 38-28 one month prior.
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