The Arizona Cardinals (10-5) are on the road for a tilt with the Dallas Cowboys (11-4) Sunday in Week 17. Kickoff is set for 4:25 p.m. ET at AT&T Stadium. Below, we look at the Cardinals vs. Cowboys odds and lines; check back for our NFL picks and predictions.
The Cardinals have lost three games in a row and are 3-5 in their last eight outings after a 7-0 start to the season, but they clinched a playoff berth thanks to losses by the San Francisco 49ers and Minnesota Vikings in Week 16.
Arizona fell 22-16 to the Indianapolis Colts Saturday and lost the division lead in the NFC West with a Los Angeles Rams victory Sunday.
The Cowboys are coming off a massive 56-14 win over the Washington Football Team in Week 16. QB Dak Prescott threw 4 touchdown passes in only three quarters before giving way to backup QB Cooper Rush as the Cowboys went on to finish with 497 yards of total offense.
CB Trevon Diggs recorded his league-leading 11th interception and DE DeMarcus Lawrence picked off a pass and returned it 40 yards for a touchdown.
Also see: All Week 17 odds and lines
Cardinals at Cowboys odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 9:13 a.m. ET.
- Money line: Cardinals +180 (bet $100 to win $180) | Cowboys -230 (bet $230 to win $100)
- Against the spread (ATS): Cardinals +4.5, -108 (bet $108 to win $100) | Cowboys -4.5, -112 (bet $112 to win $100)
- Over/Under (O/U): 49.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Cardinals 10-5 | Cowboys 11-4
- ATS: Cardinals 9-6 | Cowboys 12-3
- O/U: Cardinals 7-8 | Cowboys 7-8
Cardinals and Cowboys head-to-head
The Cardinals and Cowboys used to be in the NFC East together and have played each other 89 times in the regular season and once in the postseason. Dallas holds a commanding 56-33-1 record in the all-time series but the Cardinals have won four of the last five meetings dating back to 2008.
They played each other last season on national television for Monday Night Football. Cardinals QB Kyler Murray threw 2 touchdown passes and rushed for another while RB Kenyan Drake rushed for 164 yards and 2 scores in a 38-10 win. Murray has never lost a game at AT&T Stadium dating back to high school.
Prescott was injured in last years’ meeting. He is 1-0 in his career against the Cardinals, giving the Cowboys their only win in the series since 2008 when the teams played in 2017.
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