Draft or pass: Which 49ers should be on your fantasy football team?

The San Francisco 49ers could become a real factor in fantasy football in 2020.

Draft: 49ers defense

Kelley L Cox-USA TODAY Sports

This may be a mistake in Week 1 when San Francisco takes on a high-octane Cardinals offense, but the next two games against the Jets and Giants should make up for it. The 49ers’ pass rush is going to generate sacks and turnovers as long as its running at full speed. Perhaps the biggest concern is the lack of takeaways in the secondary last season. Of their 12 interceptions last season, just seven came from defensive backs. There could be a positive regression in that area, but it could also be a flaw that holds this defense back from a fantasy perspective.