Detroit Lions at San Francisco 49ers odds, picks and predictions

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The Detroit Lions (13-2) and the San Francisco 49ers (6-9) meet for Monday Night Football at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 8:15 p.m. ET (ESPN / ABC). Let’s analyze BetMGM Sportsbook’s NFL odds around the Lions vs. 49ers odds, and make our expert NFL picks and predictions.

The Lions doubled up the Chicago Bears 24-17 in Week 16, cashing as 6.5-point favorites at Soldier Field as the Over (47.5) cashed. The cover halted an 0-3 against the spread (ATS) skid, while the Over has cashed in 3 consecutive outings for Detroit.

Detroit is in the mix for the No. 1 overall seed, trying to hold off the Minnesota Vikings. Those teams meet next week, and it could be the winner receiving the No. 1 seed, and the loser dropping all the way to the No. 5. But, first things first, we have to get through Week 17.

The 49ers are eliminated from playoff contention as the injuries have just piled up for the defending NFC champs. San Francisco has dropped 5 of the past 6 games, while going a dismal 1-6 ATS in the past 7 outings, while the Over is 3-1-1 in the previous 5 outings.

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Lions at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 5:38 p.m. ET.

Moneyline (ML): Lions -200 (bet $200 to win $100) | 49ers +165 (bet $100 to win $165)
Against the spread (ATS): Lions -3.5 (-110) | 49ers +3.5 (-110)
Over/Under (O/U): 50.5 (O: -110 | U: -110)

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Lions at 49ers key injuries

Lions

RB David Montgomery (knee) out
WR Kalif Raymond (foot) out
LB Jalen Reeves-Maybin (neck) questionable

49ers

OL Aaron Banks (knee) out
DL Robert Beal Jr. (ankle) out
LB Tatum Bethune (knee) questionable
S Ji’Ayir Brown (ankle) questionable
OL Spencer Burford (calf) out
LB Dre Greenlaw (calf) out
OL Colton McKivitz (knee) questionable
CB Charvarius Ward (personal) questionable

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Lions at 49ers picks and predictions

Prediction

Lions 33, 49ers 19

Moneyline

Playing the Lions (-200) straight up is a little too expensive, costing you 2 times your potential return. However, backing Detroit as part of a multi-leg parlay is a good idea, as it isn’t too expensive, and there is still plenty of value on a ticket of 3 or more teams.

PASS.

Against the spread

The LIONS -3.5 (-110) are laying a surprisingly low number considering what is at stake. The Lions are battling for the No. 1 overall seed, trying to secure home-field advantage in the playoffs. The 49ers +3.5 (-115) are eliminated from playoff contention, and they’re banged up. It’s hard to imagine there will be much of a fight.

Over/Under

OVER 50.5 (-110) is the lean, but go with a half-unit play at most.

The Over is 3-1-1 in the past 5 games for the 49ers, but be careful, as the Under is 4-2 in the past 6 outings at home.

For the Lions, it’s all about the Over, going 3-0 in the past 3 games, while scoring 34 or more points in each of the outings. The Lions offense has managed 23 or more points in 12 consecutive contest, too, while allowing 20 or more points in 3 of the previous 4 outings.

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