Dallas Cowboys at San Francisco 49ers odds, picks and predictions

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The Dallas Cowboys (3-3) take on the San Francisco 49ers (3-4) on Sunday Night Football. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.

The Cowboys were punked in a 47-9 home defeat to the Detroit Lions before their bye last week. Dallas is now 0-3 at home and 3-0 on the road. QB Dak Prescott was 17-for-33 for 178 yards, 0 TDs and 2 INTs. WR CeeDee Lamb did what he could with 7 catches for 89 yards on 14 targets.

The Niners were upended 28-18 at home by the Kansas City Chiefs last week as 2-point favorites. QB Brock Purdy threw 3 picks, but he was able to run in 2 touchdowns. They also lost star WR Brandon Aiyuk (knee) to a torn ACL and MCL for the season. WR Deebo Samuel (wrist, illness) and TE George Kittle (foot) are both questionable this week, and the 49ers’ options are wearing thin.

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Cowboys at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 1:56 a.m. ET.

Moneyline (ML): Cowboys +180 (bet $100 to win $180) | 49ers -225 (bet $225 to win $100)
Against the spread (ATS): Cowboys +4.5 (-110) | 49ers -4.5 (-110)
Over/Under (O/U): 47 (O: -110 | U: -110)

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Cowboys at 49ers key injuries

Cowboys

CB DaRon Bland (foot) out
LB Eric Kendricks (shoulder) questionable
DE Micah Parsons (ankle) out
DT Jordan Phillips (wrist) out
LB Nick Vigil (foot) questionable

49ers

WR Brandon Aiyuk (knee) out
WR Jauan Jennings (hip) out
TE George Kittle (foot) probable
CB Deommodore Lenoir (illness) questionable
RB Christian McCaffrey (Achilles) out
PK Jake Moody (ankle) out
WR Deebo Samuel (wrist, illness) probable

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Cowboys at 49ers picks and predictions

Prediction

49ers 24, Cowboys 17

Moneyline

The Cowboys are reeling on defense without DE Demarcus Lawrence (foot) and Parsons. Their pass rush has been awful. As a defensive team, they’re the worst in fantasy over the last 5 weeks and have just 7 sacks in that span. The Niners have won 3 matchups in a row, and the Cowboys haven’t defeated them since 2020.

The Niners should win this game, but they’re nowhere near worth dropping -225 on.

Instead, I’m rolling with BROCK PURDY OVER 18.5 RUSHING YARDS (-110). He has hit this number 3 games in a row.

Against the spread

I’m rolling with 49ERS -4.5 (-110) here. They’ve defeated the Cowboys by 5+ points in each of their 3 consecutive victories over them. The lack of a Dallas pass rush should give Purdy the time to pick them apart.

Over/Under

This number looks a little high at first glance.

The Under has cashed in 2 of the last 3 meetings. It has cashed in 2 of the last 3 Niners games and 2 of the last 3 Cowboys games.

Take the UNDER 47 (-110).

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Looking to check out the latest NFL odds and perhaps make a wager or two? Our guide to NFL betting apps breaks down the top features and offers from BetMGM, Caesars, Fanatics Sportsbook and more.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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