Dallas Cowboys at San Francisco 49ers odds, picks and predictions

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The Dallas Cowboys (3-1) take a trip to California to visit the San Francisco 49ers (4-0) Sunday. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Below, we analyze BetMGM Sportsbook’s lines around the Cowboys vs. 49ers odds, and make our expert NFL picks and predictions.

Dallas handed coach Bill Belichick the worst loss of his career in a 38-3 victory Sunday, covering as a 6-point favorite. QB Dak Prescott was solid in the win as he completed 28 of his 34 passes for 261 yards and 1 TD, but the defense was the star of that show. The Boys’ defense scored on both a fumble return TD and an interception return TD in the 2nd quarter while also racking up 3 turnovers, 2 sacks and 4 tackles for loss.

San Francisco covered as a 14.5-point favorite in a 35-16 win over the Arizona Cardinals Sunday. Both QB Brock Purdy and RB Christian McCaffrey were stellar in the win. Purdy set a new 49ers franchise record in completion percentage (95%) as he completed 20 of his 21 passes for 283 yards, 1 TD and 1 rushing TD. McCaffrey set a new career high in TDs in a game (4) as he ran for 3 on the ground and caught a 6-yard TD pass.

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Cowboys at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:25 p.m. ET.

Moneyline (ML): Cowboys +145 (bet $100 to win $145) | 49ers -175 (bet $175 to win $100)
Against the spread (ATS): Cowboys +3.5 (-120) | 49ers -3.5 (+100)
Over/Under (O/U): 45 (O: -110 | U: -110)

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Cowboys at 49ers key injuries

Cowboys

LB Damone Clark (shoulder) questionable
TE Peyton Hendershot (ankle) questionable
S Malik Hooker (shoulder) questionable
LB Micah Parsons (knee) questionable

49ers

OG Jon Feliciano (concussion) questionable
LB Dre Greenlaw (ankle) questionable
WR Jauan Jennings (shin) questionable
RB Elijah Mitchell (knee) out
WR Deebo Samuel (knee/ribs) questionable
CB Charvarious Ward (heel) questionable

Cowboys at 49ers picks and predictions

Prediction

49ers 24, Cowboys 20

Moneyline

PASS.

I like the 49ers to pick up their 3rd-consecutive win vs. Dallas, but a -185 favorite is not worth the risk. Bet on the spread and/or total instead.

Against the spread

LEAN 49ERS -3.5 (+100).

This 49ers team is on a roll right now as McCaffrey has scored a TD in 13 straight games, and Purdy is still undefeated in the regular season as a starter (9-0). The Cowboys’ defense is real, and I expect them to make things tough on this Niners offense. However, Prescott has proven to be turnover prone in big moments, especially when trailing, and I expect that trend to continue here and help the Niners cover.

Over/Under

BET UNDER 45 (-110).

San Francisco ranks 2nd in total offense, averaging 398 yards per game, but both of these teams are known for their defenses. Dallas’ defense ranks 2nd in total yards allowed per game (259.8) while San Francisco’s defensive unit ranks 5th (284.3). I expect both teams’ edge rushers to make life hard on these QBs and look for each to throw at least 1 interception. This will be a close game filled with defense and not much explosive offense.

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