The Indianapolis Colts (0-0) are set to visit the Houston Texans (0-0) at NRG Stadium on Sunday to begin the 2022 NFL season.
While the Colts haven’t won an opening day game since 2013, they are heavily favored to snap that streak against the Texans. In terms of the spread, the Colts are the biggest favorites of the week, according to Tipico Sportsbook.
Here is the game information for the Week 1 matchup: