The Indianapolis Colts (0-0) made the trip south to NRG Stadium and are preparing to commence the 2022 NFL season with a divisional matchup against the Houston Texans (0-0) on Saturday.
Opening as the largest favorites on the week, according to Tipico Sportsbook, the Colts are expected to take care of business on the road. No game in the NFL is ever a cakewalk, but the majority of fans and analysts are expecting the Colts to walk away with a win.
Here are the biggest storylines going into the Week 1 matchup: