The Indianapolis Colts (2-1) and Los Angeles Rams (1-2) released their lists of inactive players ahead of the Week 4 matchup at Lucas Oil Stadium.
Here are the inactive players for the Colts in Week 4:
| Name | Position | Injury |
| Bernhard Raimann | OT | Concussion |
| Ryan Kelly | C | Concussion |
| Sam Ehlinger | QB | — |
| Darrell Baker Jr. | CB | — |
| Will Mallory | TE | — |
| Cameron McGrone | LB | — |
| Isaiah Land | LB | — |
Notes
- G Quenton Nelson (toe) and DT DeForest Buckner (groin/back) were questionable on the final injury report but are active for Week 4.
- QB Sam Ehlinger was on the injury report with a right shoulder injury but will serve as the emergency third quarterback, suggesting he would be healthy enough to play if needed.
- With LT Bernhard Raimann inactive, rookie Blake Freeland will be the starter at left tackle.
- Rookie DT Adetomiwa Adebawore is active for the first time this season.
Here are the inactives for the Rams in Week 4:
| Name | Position | Injury |
| Alaric Jackson | OT | Hamstring |
| Zach Evans | RB | — |
| Zach Thomas | OL | — |
| Earnest Brown IV | DL | — |
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