Colts vs. Patriots: Prediction, point spread, best bet in Week 10

Here’s the betting preview for Week 10.

The Indianapolis Colts (4-5) play the New England Patriots(2-7) on Sunday, and if you’re looking to do some last-minute betting research, you’re in luck! We’ll give you the latest point spread, money line odds and over/under number, as well as the information you’ll need to make the smartest bet.

The game starts at 4:05 p.m. ET and can be seen on NFL Network.

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The Colts ended their three-game losing streak with a road win in Week 9 and now travel to Germany to take on the Patriots, who have lost five of their last six and hold the worst record in the AFC. These two teams have met twice since the Tom Brady era ended, splitting those games 1-1. The Colts won the matchup in 2021 while the Patriots dominated their win in 2022.

  • Point spread: Colts -1.5
  • Money line: -130 Colts / +110 Patriots
  • Over-under: 43

Colts vs. Patriots injury report:


Check out the latest injury report here.

Advice and prediction

Michael Pittman Jr. OVER 65.5 receiving yards (-115)

There’s no telling how the overseas game will pan out, but one constant throughout the entire season for the Colts has been their leader in the wide receiver room. Only two players have at least eight receptions in two games this season. One is Tyreek Hill. The other is Pittman. He has reached 60 or more receiving yards in three out of his last four games while the Patriots have allowed the fifth-most receiving yards to wideouts over the last five weeks. With Josh Downs potentially missing this game or being extremely limited due to a knee injury, it wouldn’t be a surprise if Pittman was the sole focus in the passing game.

Prediction: Colts 23, Patriots 20

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Get more betting analysis and predictions at Sportsbook Wire.