The Indianapolis Colts (3-2) and Jacksonville Jaguars (3-2) are just about set for a crucial Week 6 matchup at TIAA Bank Field.
As the second meeting between these division-mates, the Colts will be looking to even the season series after the Jaguars came out victorious in Week 1 on the road. Meanwhile, the Colts haven’t defeated the Jaguars on the road since the 2014 season, enduring an eight-game losing streak.
Vegas has the Colts sitting as 4.5-point underdogs in this matchup, according to BetMGM.
Here’s how the experts around the league see this matchup shaking out:
| Expert | Pick | Score (if applicable) | Link |
| Nate Davis (USA TODAY) | Jaguars | 24-17 | Link |
| Jarrett Bell (USA TODAY) | Jaguars | 27-20 | Link |
| Lorenzo Reyes (USA TODAY) | Jaguars | 25-23 | Link |
| Mike Clay (ESPN) | Jaguars | — | Link |
| Dan Graziano (ESPN) | Jaguars | — | Link |
| NFL Network | Jaguars | 24-21 | Link |
| Bill Bender (Sporting News) | Jaguars | 28-26 | Link |
| Pete Prisco (CBS Sports) | Jaguars | 27-20 | Link |
| Cam DaSilva (Sportsbook Wire) | Jaguars | — | Link |
| Bleacher Report | Jaguars | 27-21 | Link |
Over at Tallysight, 90% of the analysts have the Jaguars walking away with a home victory. In terms of the 4.5-point spread, 63% of analysts believe the Jaguars will cover.
This is a pretty heavy turn toward the Jaguars. They are coming off two impressive wins in London, and they took care of business on the road against the Colts in Week 1 so it doesn’t come as a surprise.
We should expect the Colts to be competitive, though. They’ve been a scrappy team all season, and they’re getting healthier despite the fact that they’ll be without Anthony Richardson.
We’ll see if the Colts can pull off the road upset when these two AFC South teams kick off at 1:00 p.m. ET on Sunday in Duval County.
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