Colts rule out Anthony Castonzo, Darius Leonard vs. Browns

Colts will be down two key starters in Week 5.

The Indianapolis Colts have ruled out left tackle Anthony Castonzo and linebacker Darius Leonard for the Week 5 matchup against the Cleveland Browns, head coach Frank Reich told the media on Friday.

Castonzo, who has been dealing with a rib injury, and Leonard, who has been dealing with a groin injury, both left the Week 4 game against the Bears with their respective ailments. Neither was able to log a practice this week and now the Colts will be down two of their key starters.

The Browns are likely the biggest test the Colts have faced thus far this season. Their rushing attack is among the best in the NFL while defensive end Myles Garrett is in line for the Defensive Player of the Year award.

These two injuries will have a massive impact on the game and could be a deciding factor in the outcome.

With Castonzo ruled out, the Colts will be rolling with backup Le’Raven Clark. He will have a monumental task ahead of him in stopping Garrett and will likely get some help from the tight ends and running backs.

With Leonard ruled out, the Colts will move forward with Anthony Walker Jr. and Bobby Okereke, both of which have been on the injury report this week with their own injuries.

The Colts are slight road favorites in the matchup against the Browns, but these two injuries are sure to have an impact on Sunday.