Cleveland Guardians at New York Yankees odds, picks and predictions

Analyzing Wednesday’s Cleveland Guardians at New York Yankees odds and lines, with MLB expert picks, predictions and best bets.

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The Cleveland Guardians (73-52) and New York Yankees (73-53) play the middle contest of a 3-game series Wednesday (Prime Video). First pitch from Yankee Stadium is set for 7:05 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Guardians vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The Guardians picked up a 9-5 victory in 12 innings in the series opener, cashing as a moderate underdog (+120) as the Over (8) easily connected. Still, the Under has cashed at a 4-2 clip in the past 6 games.

The 9-run offensive explosion for Cleveland was a bit surprising, as it  managed a total of just 4 runs in a 3-game interleague series sweep at the hands of the Milwaukee Brewers over the weekend.

The good news is that the Yankees managed 5 runs, equaling their total for the entire 3-game series loss in Detroit. However, New York also allowed 9 runs, and it has surrendered 7 or more runs in 6 of the past 12 outings.

It’s been a roller coaster ride for Cleveland lately, winning 5 in a row from July 28-Aug. 2, before dropping 7 straight from Aug. 3-9. The Guardians then won 5 in a row from Aug. 10-14, and they’ve now dropped the past 3.

Guardians at Yankees projected starters

LHP Joey Cantillo vs. LHP Nestor Cortes

Cantillo (0-2, 6.23 ERA) makes his 4th career start. He has a 1.62 WHIP, 4.2 BB/9 and 6.2 K/9 in 13 IP.

  • Last start: Loss, 5 2/3 IP, 3 ER, 5 H (2 HR), 3 BB, 2 K in 4-2 road setback vs. Minnesota Twins Friday
  • 2024 road splits: 0-1, 6.00 ERA (9 IP, 6 ER), 1.67 WHIP, .265 opponents’ batting average (OBA), 6 BB, 5 K in 2 starts
  • Has never faced Yankees

Cortes (6-10, 4.20 ERA) makes his 26th start. He has a 1.19 WHIP, 1.9 BB/9 and 8.5 K/9 in 141 1/3 IP.

  • Last start: Win, 7 IP, 0 ER, 3 H, 0 BB, 9 K in 4-1 road victory vs. Chicago White Sox Aug. 13
  • 2024 home splits: 4-5, 3.05 ERA (73 2/3 IP, 25 ER), 0.96 WHIP, .224 OBA, 10 HR, 10 BB, 68 K in 12 starts
  • Career vs. Guardians: 1-0, 3.68 ERA (22 IP, 9 ER), 0.82 WHIP, 9.8 K/9 in 6 appearances (3 starts)

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Guardians at Yankees odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:56 a.m. ET.

  • Moneyline (ML): Guardians +136 (bet $100 to win $136) | Yankees -162 (bet $162 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-160) | Yankees -1.5 (+132)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Guardians at Yankees picks and predictions

Prediction

Yankees 6, Guardians 3

Moneyline

The YANKEES (-162) are a solid play for the bounce back on Wednesday night after losing in extras in the high-scoring series opener.

Cantillo has struggled in the early going, but Cleveland has had to thrust him into action due to a multitude of injuries in the starting rotation. Manager Stephen Vogt and his pitching staff has done it with mirrors, but trust Cortes and the home side to get it done here.

Run line/Against the spread

If you’re a little less conservative, play YANKEES -1.5 (+132) to get the job done by at least 2 runs, rather than simply playing the moneyline, which is a safer play.

New York has lost 3 in a row, so there is plenty of risk here. However, in its past 6 wins, 5 of those victories have come by 2 or more runs.

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Over/Under

OVER 8.5 (-110) is the lean, but play a half-unit at the most.

The Over cashed in the series opener, with 14 combined runs. That snapped a 3-game run to the Under for the Yankees, with an average total of just 4.0 runs per game in the 3-game set in Detroit over the weekend.

Cleveland has split the Over and Under 2-2 in the past 4 games, and the total has split 3-3-1 in the past 7 road contests, too, so be careful, and go lightly.

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You may love betting on sports, but until college football and the NFL seasons officially start, the pickings can get slim. You can fill some of that time and scratch that itch at online casinos and enjoy slots, blackjack, video poker and more.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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