Cleveland Guardians at Cincinnati Reds odds, picks and predictions

Analyzing Wednesday’s Cleveland Guardians at Cincinnati Reds odds and lines, with MLB expert picks, predictions and best bets.

The Cleveland Guardians (58-62) and Cincinnati Reds (62-59) meet Wednesday for the finale of a 2-game series. First pitch from Great American Ball Park is set for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Guardians vs. Reds odds and make our expert MLB picks and predictions for the best bets.

Season series: Guardians lead 1-0

Cleveland won 3-0 as +108 road underdogs on Tuesday. The Guardians scored on a 2-run single from 1B Kole Calhoun and scored a run on a Reds’ fielding error.

The Guardians have now won back-to-back games and are 4-6 in their last 10. Cleveland is 27-34 on the road. The Reds have now lost 2 of their last 3 and are 3-7 in their last 10. Cincinnati is 29-32 at home.

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Guardians at Reds projected starters

RHP Noah Syndergaard vs. LHP Andrew Abbott

Syndergaard (2-5, 6.35 ERA) makes his 16th start. He has a 1.40 WHIP, 1.6 BB/9 and 5.7 K/9 in 72 1/3 innings.

  • Last outing: Win, 5 2/3 IP, 1 ER, 6 H, 2 BB, 5 K in a 4-3 home win Thursday vs. Toronto Blue Jays
  • Career vs. Cincinnati: 7-0, 3.02 ERA (59 2/3 IP, 20 ER), 1.00 WHIP, 8.7 K/9 in 9 starts

Abbott (7-3, 2.95 ERA) makes his 14th career start. The rookie has a 1.11 WHIP and 9.8 K/9 in 76 1/3 innings.

  • Last outing: Win, 5 2/3 IP, 2 ER, 4 H, 0 BB, 9 K in a 9-2 road win Friday vs. Pittsburgh Pirates
  • First start vs. Cleveland

Guardians at Reds odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 11:21 p.m. ET.

  • Moneyline (ML): Guardians +135 (bet $100 to win $135) | Reds -160 (bet $160 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-145) | Reds -1.5 (+120)
  • Over/Under (O/U): 9.5 (O: -115 | U: -105)

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Guardians at Reds picks and predictions

Prediction

Reds 4, Guardians 3

Moneyline

LEAN REDS (-160).

The Reds have been on a bit of a cold streak recently, but the Guardians have not been much better. The Guardians are a slightly worse road team than the Reds are a home team. Syndergaard has struggled this season for Cincinnati, but his dominance throughout his career vs. Cleveland is what gives the Reds the slight edge here.

At (-160) this line is a bit risky, if you aren’t comfortable betting the juice then play the run line and/or O/U instead.

Run line/Against the spread

LEAN GUARDIANS +1.5 (-145).

These teams are very evenly matched and I like that the Guardians are carrying more momentum into this one than Cincinnati. The Guardians do hold a 6-4 lead in the last 10 matchups, but Cleveland’s road struggles is what will help Cincinnati pull out the win. Look for Cleveland to put up a good fight and claw to within 1-run at the very minimum.

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Over/Under

BET UNDER 9.5 (-105).

For Cleveland the Under is 6-4 in their last 10 overall and 2-1 in Syndergaard’s last 3 starts vs. Cincinnati. For Cincinnati the Under is 8-2 in their last 10 and 3-2 in Abbott’s last 5 starts overall.

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