Cleveland Browns at New England Patriots odds, picks and prediction

Analyzing Sunday’s Cleveland Browns at New England Patriots Week 10 odds and lines, with expert NFL picks, predictions and best bets.

The Cleveland Browns (5-4) travel to meet the New England Patriots (5-4) Sunday for a Week 10 matchup at Gillette Stadium in Foxboro, Mass. Kick-off is scheduled for 1 p.m. ET. Below, we look at the Browns vs. Patriots odds and lines, and make our best NFL picks, predictions and bets.

The Browns picked up a huge win at Cincinnati last week, winning 41-16. That’s the good news. The bad news is the Browns will be without RB Nick Chubb, as he is on the reserve/COVID list, so RB D’Ernest Johnson will get the start.

The Patriots also have issues in the backfield, as RB Damien Harris is out with a concussion. RB Rhamondre Stevenson is still in the protocol and has a chance.

If not, it will be RB Brandon Bolden tasked with the start.

Browns at Patriots odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:15 p.m. ET.

  • Money line: Browns +110 (bet $100 to win $110) | Patriots -135 (bet $135 to win $100)
  • Against the spread (ATS): Browns +2.5 (-108) | Patriots -2.5 (-112)
  • Over/Under (O/U): 44.5 (O: -112 | U: -108)

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Browns at Patriots key injuries

Browns

  • RB Nick Chubb (reserve/COVID) out
  • LB Jeremiah Owusu-Koramoah (ankle) questionable
  • CB Greedy Williams (shoulder) questionable

Patriots

  • RB Damien Harris (concussion) out
  • LB Dont’a Hightower (ankle) questionable
  • TE Jonnu Smith (shoulder) questionable
  • RB Rhamondre Stevenson (concussion) questionable
  • LB Kyle Van Noy (groin) questionable

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Browns at Patriots odds, lines, predictions and picks

Prediction

Patriots 22, Browns 19

Money line

The PATRIOTS (-135) are a good play if you want to avoid the points. This isn’t terribly out of line or expensive. With so many uncertainties at key positions on both sides of the ball, this is the way to go.

Against the spread

The PATRIOTS -2.5 (-112) are worth playing lightly, although I’d prefer to just play them straight up. The Browns +2.5 (-108) are 11-29-2 ATS across the past 43 against winning teams, although they are 5-1 ATS in the past six as a road underdog.

New England has owned this series, at least against the number, going 6-2 ATS in the past eight meetings, including 4-1 ATS in the past five in Foxboro. But all of that success was with a guy named QB Tom Brady under center.

Over/Under

The UNDER 44.5 (-108) is worth a look, as both teams will have key personnel either sidelined or not at 100 percent.

My only concern is that with both teams missing key parts of the run game, perhaps there is more of an aerial attack. Passing is never good for the Over.

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