The Clemson Tigers (5-3, 4-2 ACC) pay a visit to Cardinal Stadium for a tilt with the Louisville Cardinals (4-4, 2-3) Saturday at 7:30 p.m. ET. Below, we look at the Clemson vs. Louisville odds and lines, and make our expert college football picks, predictions and bets.
Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.
Clemson defeated Florida State 30-20 last Saturday. The Tigers held the Seminoles to just 241 total yards and a combined 4-for-14 mark on third and fourth downs.
As shaky as Clemson has been offensively this season (113th FBS in yards per game and points per game), the Tigers have been solid stopping opponents. Clemson has held foes to 15.3 points per game, which ranks third nationally.
The Cardinals were on the downside of a 28-13 game at NC State last Saturday. Louisville returns home after losing three of its last four games overall. The Cards are 5-1 in their last six home games dating back to last season.
Clemson at Louisville odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 10:05 a.m. ET.
- Money line: Clemson -190 (bet $190 to win $100) | Louisville +155 (bet $100 to win $155)
- Against the spread (ATS): Clemson -3.5, -108 | Louisville +3.5, -112
- Over/Under (O/U): 46.5, O: -112 | U: -108
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Clemson at Louisville odds, lines, picks and predictions
Prediction
Louisville 24, Clemson 21
Money line
Clemson is perhaps getting a bit too much of a recency bias boost here. It comes after a win over a brand name Florida State, but FSU is a shaky-at-best brand in its current state. The Tigers’ offense is just simply in permanent-fade purgatory.
In points allowed vs. yardage allowed, the Clemson defense is out too far over its skis. The opposite holds true for Louisville.
BACK THE CARDINALS (+155).
Against the spread
The Tigers are 0-5 ATS in their last five games following a straight-up win.
The Cardinals are 6-0 ATS in their last six games after scoring less than 20 points in their previous game and 6-3 ATS across their last nine conference home games.
With Clemson playing its third road game in four weeks, BACK LOUISVILLE +3.5 (-112).
Over/Under
Too many reasons to not line both sides of this figure: PASS.
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