Defense
| Pos. | First | Second | Third |
| LDE | Alex Okafor | Emmanuel Ogbah | |
| LDT | Chris Jones | Khalen Saunders | |
| RDT | Derrick Nnadi | Mike Pennel | Joey Ivie |
| RDE | Frank Clark | Tanoh Kpassagnon | |
| LB | Anthony Hitchens | Ben Niemann | Reggie Ragland |
| LB | Damien Wilson | Darron Lee | Dorian O’Daniel |
| LCB | Charvarius Ward | Rashad Fenton | Mo Claiborne |
| RCB | Bashaud Breeland | Rashad Fenton | |
| CB | Kendall Fuller | Rashad Fenton | |
| FS | Juan Thornhill | Daniel Sorensen | |
| SS | Tyrann Mathieu | Jordan Lucas | Armani Watts |
Observations:
- It’s been reported that defensive end Emmanuel Ogbah will have season-ending surgery on a torn pectoral muscle. The Chiefs have yet to send him to injured reserve so he remains on the depth chart for Week 11.
- Defensive tackle Joey Ivie remains behind Mike Pennel on the depth chart despite Pennel being made inactive for Week 10 in favor of Ivie.