Chicago White Sox at New York Yankees odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at New York Yankees odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (27-35) play the 2nd game of a 3-game series against the New York Yankees (36-26) on Wednesday at Yankee Stadium. First pitch is scheduled for 7:05 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: White Sox lead 1-0

The White Sox defeated the Yankees 3-2 on Tuesday to extend their win streak to 4 games. Chicago is now 4 1/2 games back of the Minnesota Twins for 1st place in the AL Central.

The Yankees tallied only 3 hits Tuesday as OF Aaron Judge missed a 2nd straight game and headed to the injured list due to a toe injury. RHP Randy Vasquez is expected to make his 2nd career start Wednesday as New York works around injuries to its rotation.

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White Sox at Yankees projected starters

RHP Lance Lynn vs. RHP Randy Vasquez

Lynn (4-6, 6.55 ERA) makes his 13th start. He has a 1.52 WHIP, 3.5 BB/9 and 10.2 K/9 through 67 1/3 IP.

  • Has given up 3 or more ER in 8 of his first 12 starts
  • Owns a 2-2 record with a 4.20 ERA, 1.17 WHIP, and 8.7 K/9 in 5 career starts against the Yankees

Vasquez (0-1, 3.86 ERA) makes his 2nd start. He has a 1.50 WHIP, 5.8 BB/9 and 11.6 K/9 through 4 2/3 IP.

  • Major league debut: Loss, 4 2/3 IP, 2 ER, 4 H, 3 BB, 6 K on May 26 vs. the San Diego Padres
  • 2023 AAA Stats: 1-6, 5.13 ERA, 1.63 WHIP, 4.9 BB/9 and 10.5 K/9 through 47 1/3 IP across 10 starts

White Sox at Yankees odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9 a.m. ET.

  • Moneyline (ML): White Sox +115 (bet $100 to win $115) | Yankees -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-175) | Yankees -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

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White Sox at Yankees picks and predictions

Prediction

Yankees 6, White Sox 4

Moneyline

Even with Judge sidelined for New York, I’ll side with the YANKEES (-140) at home on Wednesday. The White Sox are 11-20 on the road compared to the Yankees being 19-14 at home this season.

Run line/Against the spread

The YANKEES -1.5 (+145) is a solid value with how poor Lynn has pitched so far this season. Lynn has a 3.24 HR/9 and .461 wOBA to left-handed batters this season, and the Yankees will run out a few of them Wednesday.

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Over/Under

OVER 8.5 (-120) is the lean in this matchup with Lynn struggling and Vasquez making just his 2nd career start. The Yankees are 5-3 to the Over in their last 8 games overall.

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