Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (15-45) and Chicago Cubs (29-31) open a 2-game set at Wrigley Field Tuesday. First pitch is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Cubs won 3-1 last season

Chicago baseball is in a serious rut. The White Sox season is depressing to watch, and they’re currently on an 11-game losing streak. The White Sox lost 6-3 at the Milwaukee Brewers Sunday despite scoring 2 runs in the top of the 1st inning. It could have been worse, as the Brewers left 6 men on base, while the White Sox left 4.

The Cubs, after a strong start to the season, have lost 8 of their last 10 games and are below .500. They fell 5-2 to the Cincinnati Reds in Chicago Sunday. They had given up 5 runs by the 3rd inning and left 9 runners on base, compared to the Reds’ 6.

White Sox at Cubs projected starters

RHP Chris Flexen vs. LHP Shota Imanaga

Flexen (2-5, 5.50 ERA) makes his 11th start and 13th appearance. He has a 1.40 WHIP, 3.7 BB/9 and 7.0 K/9 in 54 innings.

  • Last start: Loss, 5 IP, 2 ER, 4 H, 5 BB, 6 K in 3-1 home loss against Toronto Blue Jays Wednesday
  • 2024 road stats: 1-2, 4.76 ERA (22 2/3 IP, 12 ER) in 3 starts and 2 relief appearances

Imanaga (5-1, 1.86 ERA) makes his 11th start. He has a 1.00 WHIP, 1.6 BB/9 and 9.2 K/9 in 58 innings.

  • Last start: Loss, 4 1/3 IP, 7 ER, 8 H, 1 BB, 1 K in 10-6 road loss to Brewers Wednesday
  • 2024 home stats: 2-0, 1.20 ERA (30 IP, 4 ER) in 5 starts

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White Sox at Cubs odds

Provided by BetMGM Sportsbook, one of the most popular betting apps; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:25 p.m. ET.

  • Moneyline (ML): White Sox +240 (bet $100 to win $240) | Cubs -300 (bet $300 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (+120) | Cubs -1.5 (-145)
  • Over/Under (O/U): 9.5 (O: -105 | U: -115)

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White Sox at Cubs picks and predictions

Prediction

White Sox 4, Cubs 3

Moneyline

I’m not saying that the White Sox (+240) will win, but there is value in picking them as underdogs. Their inter-league record (5-12) is better than any other opponent by division; their 5-14 record against the AL East is their next best category.

But since they are also at plus money on the run line, I will PASS here.

Run line/Against the spread

The Cubs have been awful recently, and while Imanaga is their top pitcher, their bullpen will still give up runs. I like the White Sox to keep things close, or potentially win.

LEAN WHITE SOX +1.5 (+120).

Over/Under

The main source of recent troubles for both teams has been offense. The White Sox are 30th in runs per game in the past 3 weeks, while the Cubs are 29th.

Imanaga is in a perfect get-right spot after a loss. But his team’s bats may not provide much insurance.

BET UNDER 9.5 (-115).

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