Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (48-72) and Chicago Cubs (61-58) wrap up their 4-game season series on Wednesday night. First pitch from Wrigley Field is set for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-1

The White Sox won 5-3 on Tuesday, but they’ve lost 3 of their last 4  after getting swept by the Milwaukee Brewers. They’re 5-5 in their last 10 games and sit 18 1/2 games out of a Wild-Card spot.

The Cubs are also 5-5 in their last 10 games, losing their last 2 games to the Toronto Blue Jays and White Sox. They’re 1 game out of aWild-Card spot and 3 1/2 games behind the Milwaukee Brewers for the NL Central lead.

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White Sox at Cubs projected starters

RHP Mike Clevinger vs. RHP Javier Assad

Clevinger (5-5, 3.55 ERA) makes his 16th start. He has a 1.30 WHIP, 3.4 BB/9 and 7.3 K/9 in 78 2/3 innings.

  • Last start: Win, 6 IP, 1 ER, 3 H, 3 BB, 6 K in 9-2 home victory vs. New York Yankees on Aug. 9
  • Road stats: 2-4, 4.85 ERA (42 2/3 IP, 23 ER) in 8 games (8 starts)
  • 1 career start vs. Cubs (regular-season): 0-0, 4.15 ERA (4 1/3 IP, 2 ER)

Assad (2-2, 3.12 ERA) makes his 4th start. He has a 1.27 WHIP, 3.9 BB/9 and 6.7 K/9 in 60 2/3 innings.

  • Last start: Win, 7 IP, 1 ER, 4 H, 1 BB, 2 K in 6-2 road victory vs. Toronto Blue Jays on Friday
  • Home stats: 0-2, 3.63 ERA (39 2/3 IP, 16 ER) in 14 games (2 starts)
  • Career vs. White Sox (regular-season): 1-0, 0.00 ERA (1 2/3 IP, 0 ER) in 1 relief appearance

White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:51 a.m. ET.

  • Moneyline (ML): White Sox +140 (bet $100 to win $140) | Cubs -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-130) | Cubs -1.5 (+110)
  • Over/Under (O/U): 11 (O: +100 | U: -120)

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White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 4

Moneyline

The Cubs are looking to bounce back from Tuesday’s 5-3 loss and are also trying to avoid losing 3 straight games for the 1st time since the All-Star break. I think they’ll do so.

Clevinger struggles on the road and hasn’t gone more than 6 innings all season, so it’ll be on the White Sox’s bullpen, which owns the 7th-highest ERA in the league. I’m just not willing to lay down a bet at -165, so PASS.

Run line/Against the spread

Of the Cubs’ last 8 wins, 6 of them have been by at least 2 runs. And before the White Sox’s win on Tuesday night, they had lost 9 of their last 13 games, so they’ve struggled as of late.

BET CUBS -1.5 (+110) to cover the run line at home.

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Over/Under

The total has gone Over in 2 of the 3 games between the Cubs and White Sox this season, but only once has the score been more than 10 runs. With the line set higher, I like the UNDER 11 (-120) Wednesday at Wrigley, even with 2 below-average starters on the mound.

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