The Chicago White Sox (16-11) square off with the rival Chicago Cubs (16-9) Saturday at Wrigley Field for an 8:15 p.m. ET first pitch. We analyze the White Sox-Cubs MLB betting odds and picks, with betting advice and tips around the matchup.
White Sox at Cubs: Projected starting pitchers
RHP Reynaldo Lopez vs. RHP Kyle Hendricks
Lopez has made one appearance this season, and it wasn’t good. At all. He coughed up four earned runs, three hits and two walks while retiring just two Minnesota Twins on July 26, a 14-2 whitewashing.
- Lopez was apparently injured in that ugly outing, landing on the 10-day injured list due to inflammation of the right shoulder.
- Lopez was a dismal 4-9 with a 6.02 ERA and .296 opponent batting average in 89 2/3 innings over 17 road starts in 2019.
Hendricks has turned in a 3-2 record, 3.31 ERA and 0.92 WHIP with 25 strikeouts in his 32 2/3 innings across five starts.
- Hendricks was on the short end of a 3-1 score against the Cardinals last time out despite a quality start.
- In fact, four of Hendricks’ five outings have been quality starts with the exception of a six-run implosion in 4 1/3 innings on July 29 at Cincinnati.
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White Sox at Cubs: Key injuries
(List of injuries around the league)
White Sox
- SP Reynaldo Lopez (shoulder) probable
- 2B Yoan Moncada (rest) questionable
Cubs
- 3B Kris Bryant (wrist) questionable
White Sox at Cubs: Odds, lines, picks and betting tips
MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated Saturday at 10:45 a.m. ET.
Prediction
Cubs 7, White Sox 4
Moneyline (ML)
The CUBS (-182) will bounce back behind Hendricks in this one after getting hammered 10-1 in the series opener Friday. The Pale Hose are just 3-7 in their past 10 sojourns to the north side, and 4-9 in the previous 13. Hendricks will get his side back on track.
New to sports betting? A $18.20 bet on the Cubs (-182) to win straight up nets a return of just $10 if they do so.
Run line/Against the spread (ATS)
The CUBS (-1.5, -106) are a sharp play on the run line, as six of their past seven victories have been by two or more runs. If you like the north siders on the moneyline, you should like them on the run line, too.
Over/Under (O/U)
OVER 10.5 (-110) has hit in three of the past four outings by Hendricks, but that’s a bit misleading. He has allowed just six earned runs in three August starts, but the Cubs offense is averaging 6.8 runs per game in his past four outings. The wind will be blowing from the south-southwest at 8 mph to the left-center field power alley. That mild breeze might be enough to help the Cubs hit the over themselves against the rusty Lopez.
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