Chicago Cubs at Milwaukee Brewers odds, picks and predictions

Analyzing Wednesday’s Chicago Cubs at Milwaukee Brewers odds and lines, with MLB expert picks, predictions and best bets.

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The Milwaukee Brewers (31-23) welcome the Chicago Cubs (28-27) to American Family Field Wednesday. First pitch in the 3rd game of the 4-game series is set for 7:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Cubs vs. Brewers odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 3-2

The Cubs beat the Brewers 6-3 Tuesday after losing the series-opening game 5-1 Monday. Chicago snapped a 5-game losing streak with the Tuesday win. It has hit a lull and is 5-10 over its last 15 games. The Cubs are just 6-8 in division games and just 13-16 on the road. They sit 2nd in the NL Central.

The Brewers, who are 13-10 at home this season and sit atop the NL Central, have won 3 of their last 5 games. They also haven’t played up to standard as of late and are just 5-6 over their last 11. Milwaukee has been strong for bettors and is 31-23 against the spread (ATS). It has dominated the division and is 14-8 in NL Central battles this season.

Cubs at Brewers projected starters

LHP Shota Imanaga vs. RHP Bryse Wilson

Imanaga (5-0, 0.84 ERA) makes his 10th start. He has a 0.91 WHIP, 1.5 BB/9 and 9.7 K/9 in 53 2/3 IP.

  • Last start: No-decision, 7 IP, 0 ER, 4 H, 1 BB, 7 K in a 1-0 home win over the Pittsburgh Pirates on May 18
  • 2024 road splits: 3-0, 0.38 ERA (23 2/3 IP, 1 ER), 20 H, 1 HR, 7 BB, 26 K in 4 starts
  • Has never faced the Brewers

Wilson (3-1, 2.86 ERA) makes his 7th start (14th appearance). He has a 1.16 WHIP, 3.5 BB/9 and 7.8 K/9 in 44 IP.

  • Last start: No-decision, 4 2/3 IP, 2 ER, 5 H, 1 BB, 3 K in a 4-2 road win over the Houston Astros on May 18
  • 2024 home splits: 0-1, 2.50 ERA (18 IP, 5 ER), 14 H, 3 HR, 9 BB, 16 K in 3 starts and 2 relief appearances
  • Career vs. Cubs: 1-2, 5.55 ERA (35 2/3 IP, 22 ER), 1.63 WHIP, 6.1 K/9 in 6 starts and 4 relief appearances

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Cubs at Brewers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:51 a.m. ET.

  • Moneyline (ML): Cubs -142 (bet $142 to win $100) | Brewers +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Cubs -1.5 (+120) | Brewers +1.5 (-144)
  • Over/Under (O/U): 7.5 (O: -118 | U: -104)

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Cubs at Brewers picks and predictions

Prediction

Brewers 4, Cubs 3

Moneyline

BET BREWERS (+120).

The Brewers may have a slight pitching disadvantage here, but they have been far better at home than the Cubs have been on the road and have been better in divisional games.

Chicago is also just 11-16 following a win while Milwaukee is 13-9 following a loss. While Imanaga has been a terrific option for the road side, Wilson’s ERA shows he’s a capable pitcher as well.

With those trends in mind, back BREWERS (+120).

Run line/Against the spread

PASS.

Avoid a run-line play. The Cubs are too risky as a run-line favorite, especially considering they are 1-4 ATS as a run-line favorite, and the Brewers are too expensive as a run-line underdog.

Over/Under

LEAN UNDER 7.5 (-104).

The Brewers have gone Under in 5 of their last 6 games and have scored a combined 9 runs through their last 3 contests. They have allowed 3 or fewer runs in 5 of those 6 games as well.

Chicago has gone Under in 3 of its last 5 and is 23-30-2 O/U on the season. The Cubs have gone Under in 4 straight games that Imanaga has started, allowing just 4 runs in all 4 of those games.

Considering those trends, back UNDER 7.5 (-104).

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