The Carolina Panthers (5-8) travel to face the Buffalo Bills (7-6) in a Week 15 matchup Sunday. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Panthers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.
The Panthers are skidding, dropping three in a row while failing to cover each. The defense has been an issue, allowing 27 or more points in each of the losses, and the Over has hit in four consecutive games for Carolina.
The Bills dropped a 33-27 overtime heartbreaker at Tampa Bay last week, which was like losing twice. The Bills erased a late 27-10 deficit to force overtime, but couldn’t stop the Bucs in OT. Buffalo enters on a 2-5-1 ATS slide.
Panthers at Bills odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:25 p.m. ET.
- Money line: Panthers +470 (bet $100 to win $470) | Bills -700 (bet $700 to win $100)
- Against the spread (ATS): Panthers +10.5 (-105) | Bills -10.5 (-115)
- Over/Under (O/U): 44.5 (O: -105 | U: -115)
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Panthers at Bills key injuries
Panthers
- CB A.J. Bouye (foot) out
- WR DJ Moore (hamstring) questionable
- OG Michael Jordan (hamstring) questionable
- OG John Miller (ankle) questionable
Bills
- WR Emmanuel Sanders (knee) doubtful
- DT Star Lotulelei (toe) questionable
Panthers at Bills odds, lines, predictions and picks
Prediction
Bills 29, Panthers 13
Money line
The Bills (-700) are going to snap back on track with a win over head coach Sean McDermott’s old team, but you can’t lay seven times your potential winnings on a team that is just one game over .500. Don’t do it.
PASS.
Against the spread
The BILLS -10.5 (-115) are 2-1-1 ATS as a double-digit favorite this season, and they’re 2-1 SU/ATS against three NFC opponents.
Buffalo is 6-1-1 ATS in the past eight against teams with a losing record, so expect the Bills to finally pull it together and put a performance together worthy of a playoff team.
Over/Under
The UNDER 44.5 (-115) hit in Buffalo’s most recent home game, but blustering, wintry conditions played a huge part in its 14-10 loss to New England on Monday night in Week 13.
The temperature will be around freezing with winds of 13-16 mph, but not too terribly for this time of year in western New York.
The Under is 5-2 in the past seven at home for the Bills and 4-1 in the past five against teams with a losing record. The Panthers’ offense has been mediocre, and the Bills’ D should shut them down for a convincing win.
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