Cardinals are double-digit underdogs to 49ers in Week 11

The banged-up 49ers are 11.5-point favorites over the 3-6-1 Cardinals in Week 11.

The Arizona Cardinals travel to Santa Clara in Week 11 to face the San Francisco 49ers for the second time in three weeks. They will do so as huge underdogs.

When the two teams played two weeks ago in Arizona, the 49ers were favored by 9.5 points.

This time, with the Cardinals on the road, they are even bigger underdogs. According to BetMGM, the 49ers are 11.5-point favorites in Week 11.

The Cardinals have begun every week this season as underdogs. Only once did they end up as favorites — in Week 3 when they faced the Carolina Panthers and Kyle Allen took over for Cam Newton at quarterback.

The 49ers are favored by that much despite having a number of key players injured. They might be missing tackle Joe Staley, receiver Emmanuel Sanders, tight end George Kittle and running back Matt Breida.

The point total is set at 45.5. The Cardinals have scored at least 25 points in five of their last six games. They have also allowed at least 25 points in every game this season.

To bet the moneyline, you can take the 49ers at -625 or the Cardinals at +445.


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