Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Friday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (15-48) welcome the Boston Red Sox (32-31) to Guaranteed Rate Field Friday for the 2nd game of their 4-game series. First pitch is set for 8:10 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Red Sox vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 1-0

The White Sox have lost 14 straight games with just 3 of those coming by 1 run and 8 of them coming at home. Chicago dropped the 1st game of the series 14-2 Thursday. Boston used two 4-run innings to jump ahead and never looked back. The White Sox are 26-37 against the spread (ATS) on the season and sit 5th in the AL Central.

The Red Sox, who are 18-13 on the road this season, have won 2 straight, splitting a series with the Atlanta Braves prior to their Thursday win. Boston has won 4 of its last 6. Despite an above-.500 record, the Red Sox sit 3rd in the AL East and are just 28-35 ATS on the season.

Red Sox at White Sox projected starters

RHP Cooper Criswell vs. LHP Garrett Crochet

Criswell (3-2, 3.92 ERA) makes his 10th start. The rookie has a 1.19 WHIP, 2.1 BB/9 and 8.5 K/9 in 43 2/3 IP.

  • Last start: Win, 5 IP, 1 ER, 4 H, 1 BB, 5 K in 6-3 home victory over Detroit Tigers Saturday
  • 2024 road splits: 1-1, 4.82 ERA (18 2/3 IP, 10 ER), 1.29 WHIP, 1 HR, 7.7 K/9 in 4 starts
  • Career vs. White Sox: 0-0, 3.38 ERA (2 2/3 IP, 1 ER), 3 H, 2 BB, 3 K in 1 relief appearance of 8-7 home victory with Tampa Bay Rays April 21, 2023

Crochet (5-5, 3.49 ERA) makes his 14th start. He has a 0.93 WHIP, 1.9 BB/9 and 12.0 K/9 in 69 2/3 IP.

  • Last start: No-decision, 6 IP, 1 ER, 5 H, 1 BB, 8 K in 4-3 road loss in 10 innings to Milwaukee Brewers Saturday
  • 2024 home splits: 3-3, 2.50 ERA (39 2/3 IP, 11 ER), 0.86 WHIP, 3 HR, 13.8 K/9 in 5 starts
  • Career vs. Red Sox: 0-1, 3.00 ERA (3 IP, 1 ER), 2.00 WHIP, 12.0 K/9 in 4 relief appearances

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Red Sox at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:03 a.m. ET.

  • Moneyline (ML): Red Sox -110 (bet $110 to win $100) | White Sox -106 (bet $106 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (+142) | White Sox +1.5 (-172)
  • Over/Under (O/U): 7.5 (O: -118 | U: -104)

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Red Sox at White Sox picks and predictions

Prediction

White Sox 5, Red Sox 4

Moneyline

BET WHITE SOX (-106).

The White Sox have lost 14 straight, so the books making this the moneyline odds is alarming.

However, it is because of Crochet’s play. The White Sox are 5-8 when he takes the mound, but he has gone at least 5 innings and allowed 2 or fewer earned runs in 7 straight games. The White Sox are 4-2 in his last 6 starts. Chicago has scored 14 runs in its last 3 games.

Meanwhile, the Red Sox have allowed 23 runs in Criswell’s last 4 starts and have lost 4 of their last 8 games. Boston is just 7-8 over its last 15 road games.

The White Sox have their bats heating up with a strong option on the mound. Expect them to snap their losing streak, and bet WHITE SOX (-106).

Run line/Against the spread

PASS.

There’s no great option on the run line. The White Sox are far too expensive as run-line underdogs. A bettor would pay almost twice the potential return for a team that’s struggled over the last few weeks.

On the flip side, the Red Sox are too risky as run-line favorites given Crochet’s strong play as of late. Ultimately, avoid a run-line play.

Over/Under

BET OVER 7.5 (-118).

The White Sox have gone Over in 4 straight games and are 5-0-1 O/U in their last 6. Chicago has scored at least 3 runs in 5 of its last 6 games and at least 5 in 3 of its last 6.

The Red Sox have gone north of the total in 5 of their last 6 games as well and allowed at least 8 runs in 2 of their last 4. Boston has been solid offensively, scoring at least 6 runs in 4 of its last 6 games.

Considering the trends for both sides, back OVER 7.5 (-118).

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