Running back
| 2017 | 2020 |
| LeSean McCoy | Devin Singletary |
| Mike Tolbert | Zack Moss |
| Jonathan Williams | TJ Yeldon |
| Cedric O’Neal | Christian Wade |
| Jordan Johnson | Antonio Williams |
| Joe Banyard | Patrick DiMarco |
| Patrick DiMarco | Reggie Gilliam |
Advantage: 2017
Buffalo’s current backfield is building some excitement, but much of it is based on one thing: Optimism. Toward the end of his Bills career, it wasn’t looking great for LeSean McCoy. But in 2017, it certainly still was. In terms of a one-two punch, the Bills are currently trying to build a mirroring imagine of what they had in 2017 with Shady and Mike Tolbert, the human bowling ball. Zack Moss might provide a more versatile skill set in terms of a one-two tandem, but the jury is still out on whether or not that will happen.