The Buffalo Bills will have a unique matchup in Week 13 against the San Francisco 49ers.
Not only is the game Buffalo’s first of the season on Monday Night Football, it’s not even at either team’s venue. The 49ers (5-6) will relocate to the home of the Arizona Cardinals, State Farm Stadium, where they’ll host the Bills (8-3) due to COVID-19.
Despite all these circumstances, the game is still the game… and things always come down to those games, within the game. With that, here are three key matchup to watch during Bills-49ers in Week 13: