Best NFL underdog picks and predictions for Week 6

Analyzing NFL Week 6 betting odds and lines, with expert predictions and picks of the 3 best underdogs to cash in on.

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Five moneyline underdogs won their games in Week 5. Another 10 underdogs covered the spread. Among the bigger surprises, the Houston Texans beat the Jacksonville Jaguars, the Las Vegas Raiders lost to the Kansas City Chiefs by only 1 point and the Dallas Cowboys beat the Los Angeles Rams.

Below, we analyze Tipico Sportsbook‘s NFL odds and lines, and tab the best NFL Week 6 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

As for our 3 best underdog picks last week, 2 of the 3 were correct, giving us a 7-8 total record on our top underdog picks for the season. Let’s see what we’ve got for this week.

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NFL underdog predictions: Week 6

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at Saturday at 10:12 a.m. ET. All games Sunday and ET unless noted.

Dallas Cowboys +6.5 (-110) at Philadelphia Eagles – 8:20 p.m. (NBC)

The Eagles only beat the Cardinals by 3 last week and were a missed field goal away from overtime. Arizona’s defense held then to just 20 points and under 400 yards. Dallas’ defense has been better than Arizona’s. They are 3rd in points allowed and 7th in yards allowed.

QB Cooper Rush has not only been reliable and safe, having avoided getting intercepted so far this season, he has made plays.

Arizona showed that teams can run the ball on the Eagles, especially if the game is close.

I almost would take the Cowboys to win outright but I’m not that confident. The Cowboys should make this a game with their stout defensive line.

Also seeAll Week 6 odds and lines

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New England Patriots (+117) at Cleveland Browns – 1 p.m (CBS)

The Patriots shut out the Lions, who were the league’s top-scoring team, in Week 6. While the Browns have scored 26 or more points in 4 of 5 games this season, the Pats have held opponents to 20 or fewer points 3 times.

The Browns’ defense is 23rd in points allowed and, even if QB Bailey Zappe starts in place of Mac Jones, New England is averaging 26.3 points per game in their last 3 contests.

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Kansas City Chiefs (+117) vs. Buffalo Bills – 4:25 p.m (CBS)

A rematch of the overtime playoff game last year that led to overtime rules changes for the postseason, both teams are 4-1 and playing well.

The Chiefs are No. 1 in scoring and have 3 games scoring 30 or more and 2 of 40 or more.

The Bills rank No. 2 in scoring and No. 1 in scoring defense.

The Chiefs have won 3 of the last 4 meetings and 6 of the last 8, even though the Bills beat them 38-20 in Kansas City last year in the regular season.

I give the Chiefs the edge here at home this time.

More NFL Week 6 picks and predictions

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