Baltimore Orioles at New York Yankees odds, picks and predictions

Analyzing Wednesday’s Baltimore Orioles at New York Yankees odds and lines, with MLB expert picks, predictions and best bets.

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The Baltimore Orioles (87-70) and New York Yankees (92-65) meet Wednesday as they continue a 3-game series in the Bronx. First pitch from Yankee Stadium is slated for 7:05 p.m. ET (ESPN+). Let’s analyze BetMGM Sportsbook’s MLB odds around the Orioles vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: Baltimore leads 7-4

The Orioles bashed a trio of home runs in taking Tuesday’s series lid-lifter 5-3. The victory marked Baltimore’s 5th win in its last 6 games at Yankee Stadium.

Tuesday’s loss marked just the Yankees’ 3rd since Sept. 11. On Wednesday night, New York will look to avoid a 2nd straight loss, something it has not encountered since Sept. 3-4.

Orioles at Yankees projected starters

RHP Zach Eflin vs. LHP Nestor Cortes

Eflin (10-9, 3.53 ERA) is making his 28th start. He has a 1.13 WHIP, 1.1 BB/9 and 7.5 K/9 in 160 2/3 IP.

  • Last outing: No-decision, 6 IP, 2 ER, 6 H, 1 BB, 5 K in 5-3 win vs. San Francisco Giants Thursday
  • Career vs. Yankees: 3-3, 2.11 ERA (47 IP, 11 ER), 39 H, 10 BB, 53 K in 8 starts

Cortes (9-10, 3.77 ERA) is making his 31st start and 32nd appearance. He has a 1.15 WHIP, 2.0 BB/9 and 8.4 K/9 in 174 1/3 IP.

  • Last outing: No-decision, 6 IP, 0 ER, 4 H, 3 BB, 6 K in 2-1 win at Seattle Mariners last Tuesday
  • Career vs. Orioles: 5-1, 2.20 ERA (57 1/3 IP, 14 ER), 43 H, 14 BB, 72 K in 11 appearances (9 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Orioles at Yankees odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 8:43 a.m. ET.

  • Moneyline: Orioles +130 (bet $100 to win $130) | Yankees -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Orioles +1.5 (-175) | Yankees -1.5 (+145)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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Orioles at Yankees picks and predictions

Prediction

Orioles 4, Yankees 3

Moneyline

Cortes has a 1.58 ERA since Aug. 13 that does not hold up to support-stats scrutiny. The Yankee southpaw is making this start on 6 days’ rest, and that interval has been problematic for him in the past. In 2024, Cortes has allowed an .873 OPS pitching on 6-plus days’ rest. Over his career, he’s held opposing bats to a .700 OPS but a .734 mark on 6 days’ rest.

Eflin has been a fine finisher over his career (.690 OPS allowed in September-October regular-season action). Look for the solid righty to give the Orioles enough of a win probability that value is created with the underdog return.

BET THE ORIOLES (+130).

Run line/Against the spread

No interest here: PASS.

Over/Under

The Under has cashed in 11 of New York’s last 16 games. The Under is 5-0 in Baltimore’s last 5 road tilts.

Both starters have good numbers against the bats they’ll see. Both sides will be in a mode to grind through the best arms in their bullpens.

With an inward breeze in the weather forecast, BACK THE UNDER 7.5 (+100).

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