Baltimore Orioles at Chicago Cubs odds, picks and predictions

Analyzing Friday’s Baltimore Orioles at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The Baltimore Orioles (43-25) and Chicago Cubs (31-37) open a 3-game set Friday at Wrigley Field. First pitch is scheduled for 2:20 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Orioles vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting of 2023; Orioles won last season’s series 3-1

The Orioles won 4-2 as -115 home favorites vs. the Toronto Blue Jays Thursday. Baltimore has won 6 of its last 7 games and is 5 games behind the Tampa Bay Rays for the lead in the AL East.

The Cubs won 7-2 as -142 home favorites vs. the Pittsburgh Pirates Thursday. Chicago is on a 3-game win streak and sits 4th in the NL Central, 3.5 games behind the division-leading Pirates.

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Orioles at Cubs projected starters

LHP Cole Irvin vs. RHP Kyle Hendricks

Irvin (1-2, 7.85 ERA) makes his 5th start and 6th appearance. He has a 1.75 WHIP, 3.9 BB/9 and 8.8 K/9 in 18 1/3 innings.

  • Last start: Win, 5 1/3 IP, 1 ER, 6 H, 0 BB, 5 K in a 6-1 win vs. Kansas City Royals Saturday
  • Only career start vs. Cubs: Loss, 4 2/3 IP, 7 ER, 7 H, 3 BB, 6 K in an 8-4 road loss May 5, 2022

Hendricks (1-2, 3.09 ERA) makes his 5th start. He has a 1.07 WHIP, 2.3 BB/9 and 5.8 K/9 in 23 1/3 innings.

  • Last start: Win, 8 IP, 0 ER, 1 H, 1 BB, 3 K in a 4-0 win at San Francisco Giants Saturday
  • Only career start vs. Orioles: No-decision, 2 IP, 2 ER, 5 H, 0 BB, 2 K in a 7-2 win at home Aug. 8, 2014

Orioles at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:05 a.m. ET.

  • Moneyline (ML): Orioles -110 (bet $110 to win $100) | Cubs -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Orioles -1.5 (+150) | Cubs +1.5 (-185)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Orioles at Cubs picks and predictions

Prediction

Orioles 5, Cubs 4

Moneyline

The Orioles have won 6 of their last 7 games and are 4-1 in their last 5 interleague games vs. teams with a losing record. The Cubs have lost last their last 4 interleague games and are just 1-4 in their last 5 after allowing 2 or fewer runs.

BET ORIOLES (-110).

Run line/Against the spread

With Irvin on the mound for Baltimore, the Cubs should be able to score enough runs to keep it close. Chicago +1.5 (-185) should hit, but there’s no need to pay the higher price on the run line when Baltimore ML is the better play. Bet Orioles ML and/or the total instead.

PASS.

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Over/Under

The Over has hit in the Cubs’ last 4 games and 7 of their last 10 at home. The Orioles are averaging 6.75 runs over their last 4 games and that coupled with Irvin’s inconsistency as a starter should help the Over cash once again Friday.

BET OVER 8.5 (-105).

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