Arizona Diamondbacks at San Diego Padres odds, picks and prediction

Analyzing Friday’s Arizona Diamondbacks at San Diego Padres odds and lines, with MLB picks and predictions.

The Arizona Diamondbacks (34-76) start a five-game road trip with the first game of a three-game series against the San Diego Padres (62-48) Friday. First pitch is 10:10 p.m. ET at Petco Park. Let’s analyze the lines around the Diamondbacks vs. Padres odds with MLB picks and predictions.

Diamondbacks LHP Caleb Smith (3-8, 5.04 ERA) makes his 13th start and 31st appearance. He has a 1.39 WHIP, 4.9 BB/9 and 10.4 K/9 through 85 2/3 IP.

  • Smith lasted only 1 2/3 innings in his last start, allowing 5 runs in a 13-0 loss to the L.A. Dodgers.
  • The Diamondbacks are 2-10 when Smith starts this season. He lost his only start this season against the Padres, allowing 4 runs (3 earned) and 5 hits in 3 innings in a 7-0 defeat.

Padres LHP Ryan Weathers (4-3, 3.65 ERA) makes his 14th start and 20th appearance. He has a 1.25 WHIP, 3.2 BB/9 and 6.5 K/9 through 66 2/3 IP.

  • He has faced the Diamondbacks once as an opener this season. The Padres won that game, 7-0, as he pitched 1 scoreless inning April 28.
  • The Padres are 1-4 in his last five starts.

Diamondbacks at Padres odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 9:42 a.m. ET.

  • Money line: Diamondbacks +180 (bet $100 to win $180) | Padres -220 (bet $220 to win $100)
  • Against the spread/ATS: Diamondbacks +1.5 (-120) | Padres -1.5 (-105)
  • Over/Under: 8.5 (O: -125 | U: +100)

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Prediction

Padres 6, Diamondbacks 3

Money line (ML)

The Diamondbacks are the worst team in the majors this season and have the league’s worst road record at 13-41. They are 3-6 against the Padres with seven games against them in the next 10 days. Smith has a 10.97 ERA in his last five starts.

The Padres’ 36 home wins this season are bested only by the Chicago White Sox but they are only 6-7 in their last 13 at Petco. Weathers is coming off his worst appearance of the season where he allowed 8 earned runs in 4 innings of a 9-4 loss to the Colorado Rockies.

Take the PADRES (-220).

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Run line/Against the spread (ATS)

At 23-31 ATS on the road, the Diamondbacks have the second-fewest road covers and third-lowest road cover percentage. All four losses in Smith’s last five starts have been by at least 2 runs.

The Padres are only 28-30 ATS at home this season and 4-5 ATS against the Diamondbacks. They have covered the spread in three straight and are 6-5 ATS in their last 11 games.

Take the PADRES -1.5 (-105).

Over/Under (O/U)

53.4% of the games at Petco Park have gone Over the projected total this season. Five of the nine games between the two teams have had totals of 9 or more runs.

10 of the Diamondbacks’ last 14 games have had totals of 9 or more runs.

Seven of the last nine games for the Padres have had totals of 9 or more runs.

Take OVER 8.5 (-125).

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