Arizona Cardinals open as favorites in Week 3 vs. Detroit Lions

The Arizona Cardinals are laying 6.5 points in Week 3 at home vs. the Detroit Lions.

The Arizona Cardinals (2-0) play their second game in a row at home in Week 3, hosting the Detroit Lions (0-2) Sunday at 4:25 p.m. ET. The Cardinals open the week as 6.5-point favorites.

Arizona is 2-0 for the first time since 2015, and quarterback Kyler Murray is making plays with his arm and his legs. He has 516 passing yards in two games and 158 rushing yards and three touchdowns. They beat the Washington Football Team 30-15 on Sunday.

Detroit lost on Sunday to the Green Bay Packers 42-21 after building a 14-3 lead. The Lions have allowed 46 second-half points in two games.

BetMGM Sportsbook opened Arizona as a -286 favorite, and Detroit is priced at +235 with a projected total of 52.5 (Over and Under both -110).

Lions at Cardinals betting odds, spread and line

Odds via BetMGM; last updated Monday at 7:30 a.m. ET. 

  • Money line: Cardinals -286 (bet $286 to win $100) / Lions35235 (bet $100 to win $24) | Bet now
  • Against the spread: Cardinals -6.5, -110 (bet $110 to win $100) / Washington +6.5, -110 (bet $110 to win $100) | Bet now
  • Total: 52.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

New to NFL betting?

At -286 odds, the Cardinals have an implied 74.09% chance of beating the Lions in Week 2, or 50/143  fractional odds. Arizona must win by a touchdown or more for the Cardinals’ -6.5 (-110) against the spread ticket to cash.

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The underdog Lions, at +235 odds, have an implied 29.85% chance of winning, or 47/20 fractional odds. If Arizona wins or loses by less than 6 points, a Washington +6.5 (-110) bet wins.

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