Arizona Cardinals favored to rebound on road vs. Carolina Panthers in Week 4

The Arizona Cardinals are the betting favorites to get back on track with a road win over the Carolina Panthers in Week 4.

The Arizona Cardinals (2-1) travel east to face the Carolina Panthers (1-2) Sunday of Week 4 at 1 p.m. ET at Bank of America Stadium in Charlotte. Below, we take a look at the early Week 4 betting odds and lines at BetMGM Sportsbook.

The Cardinals were tripped up by the winless Detroit Lions at home by a 26-23 score on a last-second field goal, losing straight up and failing to cover for the first time this season. The under connected for the third time in as many games for Arizona. The defense is allowing just 20.3 points per game.

The Panthers were six-point underdogs at SoFi Stadium in Los Angeles against the Chargers, and they were playing their first full game without injured superstar RB Christian McCaffrey (ankle). The defense stepped up, and the Panthers were able to scratch out a gritty 21-16 win, first of the season for Carolina.

Cardinals at Panthers betting odds, spread and line

Odds via BetMGM; last updated Monday at 9 a.m. ET. 

  • Money line: Cardinals -193 (bet $193 to win $100) / Panthers +160 (bet $100 to win $160) | Bet now
  • Against the spread: Cardinals -3.5, -110 (bet $110 to win $100) / Panthers +3.5, -110 (bet $110 to win $100) | Bet now
  • Total: 50.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

New to NFL betting?

At -193 odds, the Cardinals have an implied 65.87% chance of beating Arizona in Week 4, or 100/193 fractional odds. Arizona must win by four or more points for the Cardinals -3.5 (-110) ATS ticket to cash.

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The underdog Panthers, at +160 odds, have an implied 38.46% chance of winning, or 8/5 fractional odds. If Carolina wins outright or loses by fewer than four points, a Panthers +3.5 (-110) bet wins.

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