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The Arizona Cardinals open the 2024 regular season on the road against the Buffalo Bills. The game kicks off Sunday at 1 p.m. ET at Highmark Stadium (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Bills odds, and make our expert NFL picks and predictions.
The Cardinals open the season with a healthy QB Kyler Murray and an improved defensive starting lineup. RB James Conner and TE Trey McBride are coming off career seasons. They are coming off a 4-win season and hope to take the next step, being competitive enough to perhaps make the playoffs.
The Bills remade their receiver room and their secondary. They have won the AFC East 4 straight years and hope to be a Super Bowl contender as QB Josh Allen leads the way.
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Cardinals at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1 p.m. ET.
- Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Bills -300 (bet $300 to win $100)
- Against the spread (ATS): Cardinals +6.5 (-110) | Bills -6.5 (-110)
- Over/Under (O/U): 47.5 (O: -105 | U: -115)
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Cardinals at Bills key injuries
Cardinals
- S Joey Blount (back) questionable
- TE Tip Reiman (ankle) questionable
- WR Xavier Weaver (oblique) out
Bills
- DE Javon Solomon (oblique) out
- DE Dawuane Smoot (toe) questionable
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Cardinals at Bills picks and predictions
Prediction
Bills 30, Cardinals 24
Moneyline
The Cardinals have not won in Buffalo since 1971. They have major question marks on defense with the pass rush, and they were bad against the run last season.
However, the Cardinals were a top-five offense over the final four games of the season and could be better with the addition of rookie WR Marvin Harrison Jr.
It won’t be enough to get the upset, so the Bills should win, and you shouldn’t bet them at -300 because it isn’t worth the action.
PASS.
Against the spread
Arizona’s offense should be able to test the Bills’ new secondary. Allen has thrown 5 INTs in his last 2 season openers, which will keep the game close.
The Cardinals went 9-8 ATS in a season they were 4-13 straight up.
Arizona is likely to have a lot of high-scoring close games. This should be one of them.
BET CARDINALS +6.5 (-110).
Over/Under
Their last matchup in 2020 in Arizona had 62 total points.
Three of the Bills’ final 4 games, including the postseason, has totals of 48 or higher.
Both teams should score points.
BET OVER 47.5 (-105).
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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