Game-winning TD pass against Broncos 2005
This game was sort of a coming out party for the 24-year-old Manning. Two nights prior, Giants players were informed that co-owners Wellington Mara and Bob Tisch were both very sick with cancer.
This was Manning’s first year as a full-time starter and the Giants trailed 23-10 in the fourth quarter to the Broncos. After a Tiki Barber touchdown cut the deficit to five, Manning would get the ball back on the Giants own 17-yard line with 3:29 left to play. The young signal caller would lead the first clutch comeback of his young career by leading the offense into the red zone with only 12 seconds to play.
From there, Manning scrambled around on the final play to find receiver Amani Toomer for the game-winning score. This comeback was even more special as the team rallied to win with their owners recently released from the hospital.