Chicago Bears at San Francisco 49ers odds, picks and predictions

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The Chicago Bears (4-8) hit the West Coast to face the San Francisco 49ers (5-7) Sunday in the late-afternoon slate. Kickoff from Levi’s Stadium is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bears vs. 49ers odds, and make our expert NFL picks and predictions.

The Bears nearly upset the 11-1 Detroit Lions Thanksgiving Day. They botched a play late in the game where they could have used a timeout and wasted precious time on the clock, which really shot them in the foot. It also cost coach Matt Eberflus his job as he was dismissed after the 23-20 defeat. QB Caleb Williams was impressive, going 20-for-39 for 256 yards, 3 TDs and 0 INTs. But it was Chicago’s sixth loss in a row.

The Niners dropped their third in a row as they couldn’t handle the blizzard-like conditions in Buffalo in a 35-10 loss to the Bills. They also lost RB Christian McCaffrey (knee) for the season, and RB Jordan Mason (shoulder) is also out for this one. They will turn to fourth-round pick Isaac Guerendo in the backfield.

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Bears at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 6:46 p.m. ET.

Moneyline (ML): Bears +145 (bet $100 to win $145) | 49ers -175 (bet $175 to win $100)
Against the spread (ATS): Bears +3.5 (-115) | 49ers -3.5 (-105)
Over/Under (O/U): 44 (O: -110 | U: -110)

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Bears at 49ers key injuries

Bears

C Ryan Bates (concussion) out
RB Roschon Johnson (concussion) out
WR D.J. Moore (quadriceps) questionable
RB D’Andre Swift (quadriceps) questionable

49ers

OG Aaron Banks (concussion) questionable
DE Nick Bosa (hip, oblique) doubtful
LB Dre Greenlaw (Achilles) out
RB Jordan Mason (shoulder) out
OT Trent Williams (knee) out

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Bears at 49ers picks and predictions

Prediction

Bears 24, 49ers 21

Moneyline

You don’t hear him talked about a lot because of the overnight sensation Washington Commanders QB Jayden Daniels became, but Williams is having a solid rookie season. He hasn’t thrown an interception in nearly 2 months.

Over the last 3 weeks, he has gone 75-for-117 (64.1%) for 827 yards (275.7 per game), 5 TDs and 0 INTs. He also rushed for 143 yards. These all came against playoff teams in the Green Bay Packers, Minnesota Vikings and Lions.

I’m picking the upset, but Williams is only part of the equation. How will the Bears stop the Niners? They’ll have to contain TE George Kittle, and the Bears are top-10 in defending the position over the last 5 weeks.

Take the BEARS +145.

Against the spread

I’m foregoing the spread since we’re picking the upset. I like CALEB WILLIAMS OVER 220.5 PASSING YARDS (-115). The Niners are severely banged up, and he has really thrown the ball well of late.

Over/Under

Both of these teams are Under teams. Chicago is 4-6 O/U in its last 10, and the Niners are 5-4-1. I have this sneaking Over, though, because the weather conditions will be a breath of fresh air for both teams. The Niners literally played in a blizzard in Buffalo last week, and while Chicago was in a dome for Thanksgiving, they had 3 straight games in the elements at Soldier Field beforehand.

Take the OVER 44 (-110).

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